Aspirin dose and six-month outcome after an acute coronary syndrome

AbstractObjectivesThis study was designed to compare the efficacy of low and intermediate aspirin doses in acute coronary syndromes.BackgroundLittle is known of the comparative efficacy of low and intermediate aspirin doses in this setting.MethodsWe compared six-month death, myocardial infarction (MI), and stroke in patients with unstable angina or acute MI discharged while receiving low (<150 mg) or intermediate (≥150 mg) aspirin therapy in the GUSTO IIb and PURSUIT trials (n = 20,521). We used multivariable analysis and performed a propensity analysis in order to adjust for baseline imbalances between the groups.ResultsAspirin doses <150 mg were prescribed to 29.9% (6,128) of patients. By six months, 6.4% of the patients (1,310 of 20,521) had a primary event, 6.2% of the patients receiving