High-density lipoprotein (HDL) has been identified as a potential target in the treatment of atherosclerotic vascular disease. The failure of torcetrapib, an inhibitor of cholesteryl ester transfer protein (CETP) that markedly increased HDL levels in a clinical trial, has called into doubt the efficacy of HDL elevation. Recent analysis suggests that failure may have been caused by off-target toxicity and that HDL is functional and promotes regression of atherosclerosis. New studies highlight the central importance of the ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 in reducing macrophage foam cell formation, inflammation, and atherosclerosis. A variety of approaches to increasing HDL may eventually be successful in treating ather...
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reducti...
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reducti...
Cardiovascular disease affects about 1.4 million Australians and was responsible for more than 45000...
High-density lipoprotein (HDL) has been identified as a potential target in the treatment of atheros...
Although recent genome-wide association studies have called into question the causal relationship be...
Although recent genome-wide association studies have called into question the causal relationship be...
Although recent genome-wide association studies have called into question the causal relationship be...
Abstract—Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol de...
The plasma levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascu...
The formation of the atherosclerotic plaque that is characterized by the accumulation of abnormal am...
Hypercholesterolemia is one of the main risk factors for the development of atherosclerosis. Among t...
Statins have been shown to decrease cholesteryl ester transfer protein activity (CETP) activity, and...
Therapeutic interventions aimed at increasing high-density lipoprotein (HDL) levels, in order to red...
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reducti...
Clinical and epidemiological studies have suggested that low plasma levels of high-density lipoprote...
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reducti...
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reducti...
Cardiovascular disease affects about 1.4 million Australians and was responsible for more than 45000...
High-density lipoprotein (HDL) has been identified as a potential target in the treatment of atheros...
Although recent genome-wide association studies have called into question the causal relationship be...
Although recent genome-wide association studies have called into question the causal relationship be...
Although recent genome-wide association studies have called into question the causal relationship be...
Abstract—Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol de...
The plasma levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascu...
The formation of the atherosclerotic plaque that is characterized by the accumulation of abnormal am...
Hypercholesterolemia is one of the main risk factors for the development of atherosclerosis. Among t...
Statins have been shown to decrease cholesteryl ester transfer protein activity (CETP) activity, and...
Therapeutic interventions aimed at increasing high-density lipoprotein (HDL) levels, in order to red...
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reducti...
Clinical and epidemiological studies have suggested that low plasma levels of high-density lipoprote...
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reducti...
In some settings increasing high density lipoprotein (HDL) levels has been associated with a reducti...
Cardiovascular disease affects about 1.4 million Australians and was responsible for more than 45000...