TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this issue of Immunity, Hasan et al. (2015) show that TREX1 also safeguards the cell against free glycan build-up in the endoplasmic reticulum, thereby preventing glycan-induced inflammation
3′ repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the ...
3\u27 repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and t...
Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabol...
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. ...
TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this is...
SummaryTREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX...
Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA repli...
Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which acti...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condit...
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV inf...
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV inf...
3′ repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the ...
3\u27 repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and t...
Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabol...
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. ...
TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this is...
SummaryTREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX...
Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA repli...
Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which acti...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condit...
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV inf...
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV inf...
3′ repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the ...
3\u27 repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and t...
Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabol...
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