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Expression of cytochrome P450 CYP1B1 in breast cancer

  • McKay, Judith A.
  • Melvin, William T.
  • Ah-See, A.K.
  • Ewen, Stanley W.B.
  • Greenlee, William F.
  • Marcus, Craig B.
  • Burke, M.Danny
  • Murray, Graeme I.
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Publication date
October 1995
Icon DOI
10.1016/0014-5793(95)01126-Y
Publisher
Published by Elsevier B.V.

Abstract

AbstractThe expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs

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