The Nobel Prize in Chemistry 2012, G protein-coupled receptors, rightly rewarded

AbstractG protein coupled receptors (GPCRs) constitute one of the major cell surface receptor families which is extensively studied. Since their discovery our understanding of GPCRs has significantly evolved and they have been a subject of two major recognitions by Nobel Prizes awarded to scientific works related to GPCRs. In this Letter to the Editor the 2012 Nobel Prize in Chemistry awarded to two GPCR experts, Professors Robert Lefkowitz and Brian Kobilka, is used in the aim to more sensibilize the scientists and the decision-makers in the Arab world and the Middle East for the interest that should been given to GPCRs. Moreover, the letter is supported by a brief sight on GPCRs and the major advances regarding their chemistry, structure, signaling, and pharmacology as well as their involvement in human diseases. Thus, I highly recommend the scientific community in the Arab world to better consider GPCRs in the academic, medical, and research programs and I hope that the 2012 Nobel Prize in Chemistry and this Letter to the Editor will be the ultimate stimulating events