In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells
The PI3K-PKB-FOXO signalling module plays a pivotal role in a wide variety of cellular processes, in...
This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) trans...
The FOXO transcription factors are in-volved in multiple signaling pathways and have tumor-suppresso...
In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly i...
The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that limit cell ...
SummaryActivated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in t...
The highly conserved Forkhead Box O (FOXO) family of transcription factors are key regulators of cel...
FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway and have b...
FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway and have b...
SummaryAKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting F...
FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, ye...
The FoxO transcription factors have been implicated in many processes including tumor suppression an...
AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting FOXO tum...
International audienceThe FOXO transcription factors are involved in multiple signaling pathways and...
SummaryActivated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in t...
The PI3K-PKB-FOXO signalling module plays a pivotal role in a wide variety of cellular processes, in...
This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) trans...
The FOXO transcription factors are in-volved in multiple signaling pathways and have tumor-suppresso...
In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly i...
The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that limit cell ...
SummaryActivated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in t...
The highly conserved Forkhead Box O (FOXO) family of transcription factors are key regulators of cel...
FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway and have b...
FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway and have b...
SummaryAKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting F...
FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, ye...
The FoxO transcription factors have been implicated in many processes including tumor suppression an...
AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting FOXO tum...
International audienceThe FOXO transcription factors are involved in multiple signaling pathways and...
SummaryActivated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in t...
The PI3K-PKB-FOXO signalling module plays a pivotal role in a wide variety of cellular processes, in...
This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) trans...
The FOXO transcription factors are in-volved in multiple signaling pathways and have tumor-suppresso...
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