The limited supply and expansion capacity of primary human hepatocytes presents major challenges for pharmaceutical applications and development of cell-based therapies for liver diseases. Now in Cell Stem Cell, two papers demonstrate efficient direct reprogramming of human fibroblasts into induced hepatocytes, which exhibit metabolic properties similar to primary hepatocytes
International audienceSince the reprogramming of human somatic cells into induced pluripotent stem c...
Human pluripotent stem cells (hPSCs) can self-renew indefinitely in vitro while maintaining the capa...
SummaryRecent studies have shown that defined factors could lead to the direct conversion of fibrobl...
SummaryThe generation of large numbers of functional human hepatocytes for cell-based approaches to ...
The generation of large numbers of functional human hepatocytes for cell-based approaches to liver d...
SummaryObtaining fully functional cell types is a major challenge for drug discovery and regenerativ...
Direct reprogramming represents an easy technique to generate hepatocyte-like cells (iHeps) from som...
Hepatocyte transplantation has been used to treat liver disease. The availability of cells for thes...
Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, 2014.203Vita. Cataloged from ...
Human induced pluripotent stem cells (iPSCs) have the capability of revolutionizing research and the...
Abstract Background Until now, there is no effective anti-fibrotic therapy available for liver cirrh...
Non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in the liver, is the ...
Hepatocyte-like cells (HLCs) generated from various human pluripotent stem cells (hPSCs), mostly ind...
Tens of millions of patients are affected by liver disease worldwide. Many of these patients can ben...
Worldwide more than 570 million people are chronically infected by the hepatitis B (HBV) or the hepa...
International audienceSince the reprogramming of human somatic cells into induced pluripotent stem c...
Human pluripotent stem cells (hPSCs) can self-renew indefinitely in vitro while maintaining the capa...
SummaryRecent studies have shown that defined factors could lead to the direct conversion of fibrobl...
SummaryThe generation of large numbers of functional human hepatocytes for cell-based approaches to ...
The generation of large numbers of functional human hepatocytes for cell-based approaches to liver d...
SummaryObtaining fully functional cell types is a major challenge for drug discovery and regenerativ...
Direct reprogramming represents an easy technique to generate hepatocyte-like cells (iHeps) from som...
Hepatocyte transplantation has been used to treat liver disease. The availability of cells for thes...
Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, 2014.203Vita. Cataloged from ...
Human induced pluripotent stem cells (iPSCs) have the capability of revolutionizing research and the...
Abstract Background Until now, there is no effective anti-fibrotic therapy available for liver cirrh...
Non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in the liver, is the ...
Hepatocyte-like cells (HLCs) generated from various human pluripotent stem cells (hPSCs), mostly ind...
Tens of millions of patients are affected by liver disease worldwide. Many of these patients can ben...
Worldwide more than 570 million people are chronically infected by the hepatitis B (HBV) or the hepa...
International audienceSince the reprogramming of human somatic cells into induced pluripotent stem c...
Human pluripotent stem cells (hPSCs) can self-renew indefinitely in vitro while maintaining the capa...
SummaryRecent studies have shown that defined factors could lead to the direct conversion of fibrobl...
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