SummaryThe anaphase-promoting complex/cyclosome (APC/C) and the spindle assembly checkpoint (SAC), which inhibits the APC/C, are essential determinants of mitotic timing and faithful division of genetic material. Activation of the APC/C is known to depend on two APC/C-interacting E2 ubiquitin-conjugating enzymes—UBE2C and UBE2S. We show that APC/C activity in human cells is tuned by the combinatorial use of three E2s, namely UBE2C, UBE2S, and UBE2D. Genetic deletion of UBE2C and UBE2S, individually or in combination, leads to discriminative reduction in APC/C function and sensitizes cells to UBE2D depletion. Reduction of APC/C activity results in loss of switch-like metaphase-to-anaphase transition and, strikingly, renders cells insensitive...
For successful mitosis, Cyclin 131 and Securin must be degraded efficiently before anaphase. Destruc...
The anaphase-promoting complex/cyclosome (APC/C) orchestrates cell cycle progression by controlling ...
AbstractThe spindle checkpoint assembly (SAC) ensures genome fidelity by temporarily delaying anapha...
The anaphase-promoting complex/cyclosome (APC/C) and the spindle assembly checkpoint (SAC), which in...
The spindle assembly checkpoint (SAC) inhibits the anaphase-promoting complex/cyclosome (APC/C) in r...
The Anaphase Promoting Complex (APC/C) is a multi-subunit ubiquitin ligase that is essential for cel...
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter ce...
The spindle checkpoint prevents chromosome mis-segregation by delaying sister chromatid separation u...
Abstract During mitosis, the genome duplicated during S-phase is synchronously and accurately segreg...
The Spindle Assembly Checkpoint (SAC) is required to block sister chromatid separation until all chr...
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle ...
Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the...
Eukaryotic cells rely on a surveillance mechanism known as the spindle checkpoint to ensure accurate...
Anaphase initiation requires ubiquitin-dependent proteolysis of crucial substrates through activatio...
Published 18 Mar 2014The spindle assembly checkpoint (SAC) prevents aneuploidy by coupling anaphase ...
For successful mitosis, Cyclin 131 and Securin must be degraded efficiently before anaphase. Destruc...
The anaphase-promoting complex/cyclosome (APC/C) orchestrates cell cycle progression by controlling ...
AbstractThe spindle checkpoint assembly (SAC) ensures genome fidelity by temporarily delaying anapha...
The anaphase-promoting complex/cyclosome (APC/C) and the spindle assembly checkpoint (SAC), which in...
The spindle assembly checkpoint (SAC) inhibits the anaphase-promoting complex/cyclosome (APC/C) in r...
The Anaphase Promoting Complex (APC/C) is a multi-subunit ubiquitin ligase that is essential for cel...
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter ce...
The spindle checkpoint prevents chromosome mis-segregation by delaying sister chromatid separation u...
Abstract During mitosis, the genome duplicated during S-phase is synchronously and accurately segreg...
The Spindle Assembly Checkpoint (SAC) is required to block sister chromatid separation until all chr...
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle ...
Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the...
Eukaryotic cells rely on a surveillance mechanism known as the spindle checkpoint to ensure accurate...
Anaphase initiation requires ubiquitin-dependent proteolysis of crucial substrates through activatio...
Published 18 Mar 2014The spindle assembly checkpoint (SAC) prevents aneuploidy by coupling anaphase ...
For successful mitosis, Cyclin 131 and Securin must be degraded efficiently before anaphase. Destruc...
The anaphase-promoting complex/cyclosome (APC/C) orchestrates cell cycle progression by controlling ...
AbstractThe spindle checkpoint assembly (SAC) ensures genome fidelity by temporarily delaying anapha...