AbstractThe macrolide antibiotic bafilomycin and the related synthetic compound SB 242784 are potent inhibitors of the vacuolar H+-ATPases (V-ATPase). It is currently believed that the site of action of these inhibitors is located on the membrane bound c-subunits of V-ATPases. To address the identification of the critical inhibitors binding domain, their specific binding to a synthetic peptide corresponding to the putative 4th transmembrane segment of the c-subunit was investigated using fluorescence resonance energy transfer (FRET), and for this purpose a specific formalism was derived. Another peptide of the corresponding domain of the c′ isoform, was checked for binding of bafilomycin, since it is not clear if V-ATPase inhibition can als...
AbstractApicularen A and the known vacuolar-type (H+)-ATPase (V-ATPase) inhibitor bafilomycin A1 ind...
ABSTRACT The osteoclast variant of the vacuolar H1-ATPase (V-ATPase) is a potential therapeutic targ...
Background: Vacuolar (H+)-ATPase (V-ATPase; V1Vo-ATPase) is a large multisubunit enzyme complex foun...
The macrolide antibiotic bafilomycin and the related synthetic compound SB 242784 are potent inhibit...
AbstractThe macrolide antibiotic bafilomycin and the related synthetic compound SB 242784 are potent...
The investigation of V-ATPases as potential therapeutic drug targets and hence of their specific inh...
The V-ATPases are ATP-dependent proton pumps, found in virtually all cells, responsible for acidific...
Applicant: SCLAVO BIOCINE SPA [IT]; The activity of inhibitors of vacuolar-type H+-ATPases in the in...
Dibutyltin-3-hydroxyflavone bromiide, Bu2Sn(of), is a fluorescent probe inhibitor of mitochondrial F...
AbstractBone resorption by the osteoclast is dependent on acidification of the bone surface by a vac...
Archazolid is a novel and highly efficient inhibitor of the V-ATPase, a ubiquitous membrane energizi...
A primary goal in antimicrobial drug design is to find molecules which inhibit key proteins in bacte...
Macrolides are potent inhibitors of FO sector of the mitochondrial F1FO-ATPase. The present work ex...
Journal The Journal of biological chemistry Rights Archived with thanks to The Journal of biological...
Increasing evidence highlights the role of the ATP synthase/hydrolase, also known as F1FO-complex, a...
AbstractApicularen A and the known vacuolar-type (H+)-ATPase (V-ATPase) inhibitor bafilomycin A1 ind...
ABSTRACT The osteoclast variant of the vacuolar H1-ATPase (V-ATPase) is a potential therapeutic targ...
Background: Vacuolar (H+)-ATPase (V-ATPase; V1Vo-ATPase) is a large multisubunit enzyme complex foun...
The macrolide antibiotic bafilomycin and the related synthetic compound SB 242784 are potent inhibit...
AbstractThe macrolide antibiotic bafilomycin and the related synthetic compound SB 242784 are potent...
The investigation of V-ATPases as potential therapeutic drug targets and hence of their specific inh...
The V-ATPases are ATP-dependent proton pumps, found in virtually all cells, responsible for acidific...
Applicant: SCLAVO BIOCINE SPA [IT]; The activity of inhibitors of vacuolar-type H+-ATPases in the in...
Dibutyltin-3-hydroxyflavone bromiide, Bu2Sn(of), is a fluorescent probe inhibitor of mitochondrial F...
AbstractBone resorption by the osteoclast is dependent on acidification of the bone surface by a vac...
Archazolid is a novel and highly efficient inhibitor of the V-ATPase, a ubiquitous membrane energizi...
A primary goal in antimicrobial drug design is to find molecules which inhibit key proteins in bacte...
Macrolides are potent inhibitors of FO sector of the mitochondrial F1FO-ATPase. The present work ex...
Journal The Journal of biological chemistry Rights Archived with thanks to The Journal of biological...
Increasing evidence highlights the role of the ATP synthase/hydrolase, also known as F1FO-complex, a...
AbstractApicularen A and the known vacuolar-type (H+)-ATPase (V-ATPase) inhibitor bafilomycin A1 ind...
ABSTRACT The osteoclast variant of the vacuolar H1-ATPase (V-ATPase) is a potential therapeutic targ...
Background: Vacuolar (H+)-ATPase (V-ATPase; V1Vo-ATPase) is a large multisubunit enzyme complex foun...