Fishing for Allergens Hiding as Prohaptens

Enzymes of the cytochrome P450 (CYP) superfamily are the most versatile and important class of drug-metabolizing enzymes, involved in the metabolism of xenobiotics to which human skin is exposed. Bergström et al. used a recombinant human CYP cocktail in ratios that simulate those found in human skin for the purpose of identifying prohapten metabolites of otherwise inert molecules