The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have lost their normal catalytic activity and gained a novel function to produce R-2-hydroxyglutarate (R-2-HG). A recent study now shows that R-2-HG can reversibly promote leukemogenesis in vitro, suggesting a therapeutic potential of targeting mutant IDH1 and IDH2
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studyin...
The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studyin...
The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have lost their ...
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of c...
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of c...
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulti...
The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and I...
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulti...
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulti...
Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α...
Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α...
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studyin...
The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studyin...
The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have lost their ...
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of c...
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of c...
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulti...
The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and I...
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulti...
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulti...
Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α...
Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α...
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
Heterozygous hotspot mutations in isocitrate dehydrogenases (IDH) IDH1 or IDH2 are frequently observ...
The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studyin...
The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studyin...
DOI
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