In a recent issue of Cell, King et al. (2013) show that mutations in the ubiquitin ligase subcomponent FBXW7 increase MYC protein levels and expand the number of leukemia-initiating cells (LICs) in Notch1-induced T-ALL. Genetic and pharmacological inhibition of MYC abolishes LIC activity with broader therapeutic implications
Disease relapse remains the major clinical challenge in treating T-cell acute lymphoblastic leukemia...
Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutation...
Identification and characterization of leukemia-initiating cells (LICs) is important to understand l...
Summary Sequencing efforts led to the identification of somatic mutations that could affect the self...
SummarySequencing efforts led to the identification of somatic mutations that could affect the self-...
Sequencing efforts led to the identification of somatic mutations that could affect the self-renewal...
Although prognosis has improved for children with T-cell acute lymphoblastic leukemia (T-ALL), 20% t...
Although prognosis has improved for children with T-cell acute lymphoblastic leukemia (T-ALL), 20% t...
Recent studies have shown that activating mutations of NOTCH1 are responsible for the majority of T ...
In chronic lymphocytic leukemia (CLL), the mechanisms controlling cell growth and proliferation in p...
Despite recent therapeutic improvements, Chronic Lymphocytic Leukemia (CLL) remains an incurable dis...
Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutation...
Prepublished online April 28 2011Cumulative evidence indicates that MYC, one of the major downstream...
Gain-of-function NOTCH1 mutations drive oncogenic MYC expression in T-ALL cells. Zhou et al. (2022) ...
Identification and characterization of leukemia-initiating cells (LICs) is important to understand l...
Disease relapse remains the major clinical challenge in treating T-cell acute lymphoblastic leukemia...
Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutation...
Identification and characterization of leukemia-initiating cells (LICs) is important to understand l...
Summary Sequencing efforts led to the identification of somatic mutations that could affect the self...
SummarySequencing efforts led to the identification of somatic mutations that could affect the self-...
Sequencing efforts led to the identification of somatic mutations that could affect the self-renewal...
Although prognosis has improved for children with T-cell acute lymphoblastic leukemia (T-ALL), 20% t...
Although prognosis has improved for children with T-cell acute lymphoblastic leukemia (T-ALL), 20% t...
Recent studies have shown that activating mutations of NOTCH1 are responsible for the majority of T ...
In chronic lymphocytic leukemia (CLL), the mechanisms controlling cell growth and proliferation in p...
Despite recent therapeutic improvements, Chronic Lymphocytic Leukemia (CLL) remains an incurable dis...
Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutation...
Prepublished online April 28 2011Cumulative evidence indicates that MYC, one of the major downstream...
Gain-of-function NOTCH1 mutations drive oncogenic MYC expression in T-ALL cells. Zhou et al. (2022) ...
Identification and characterization of leukemia-initiating cells (LICs) is important to understand l...
Disease relapse remains the major clinical challenge in treating T-cell acute lymphoblastic leukemia...
Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutation...
Identification and characterization of leukemia-initiating cells (LICs) is important to understand l...
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