PurposePatients with unresectable, relapsed, or refractory osteosarcoma need a novel therapeutic agent. Metformin is a biguanide derivative used in the treatment of type II diabetes, and is recently gaining attention in cancer research.MethodsWe evaluated the effect of metformin against human osteosarcoma. Four osteosarcoma cell lines (KHOS/NP, HOS, MG-63, U-2 OS) were treated with metformin and cell proliferation was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell cycle progression and apoptosis were evaluated using flow cytometric analysis, and migration and wound healing assay were performed. Fourteen female Balb/c-nude mice received KHOS/NP cell grafts in their thigh, and were allowed access to m...
Metastasis is an intricate process by which a small number of cancer cells from the primary tumor si...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Abstract Background Metformin, which is widely used as an antidiabetic agent, has recently been repo...
Metformin has been one of the most widely prescribed oral medications for type II diabetes for over ...
In recent years, several studies have presented evidence suggesting a potential role for metformin i...
Abstract Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line tre...
International audienceMetformin is a widely used antidiabetic agent, which regulates glucose homeost...
Metformin is an anti-hyperglycemic biguanide drug that is widely used as the first-line prescription...
Metformin has been used for a long time as an antidiabetic medication for type 2 diabetes. It is use...
International audienceGastric cancer is the third leading cause of cancer-related deaths worldwide a...
Abstract Biguanides have been developed for the treatment of hyperglycemia and type 2 diabetes. Rece...
Epidemiology studies have found that type 2 diabetics treated with metformin are at a lower risk for...
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs ta...
Glioblastoma multiforme (GBM) is one of the most common and deadliest cancers of the central nervous...
Metastasis is an intricate process by which a small number of cancer cells from the primary tumor si...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Abstract Background Metformin, which is widely used as an antidiabetic agent, has recently been repo...
Metformin has been one of the most widely prescribed oral medications for type II diabetes for over ...
In recent years, several studies have presented evidence suggesting a potential role for metformin i...
Abstract Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line tre...
International audienceMetformin is a widely used antidiabetic agent, which regulates glucose homeost...
Metformin is an anti-hyperglycemic biguanide drug that is widely used as the first-line prescription...
Metformin has been used for a long time as an antidiabetic medication for type 2 diabetes. It is use...
International audienceGastric cancer is the third leading cause of cancer-related deaths worldwide a...
Abstract Biguanides have been developed for the treatment of hyperglycemia and type 2 diabetes. Rece...
Epidemiology studies have found that type 2 diabetics treated with metformin are at a lower risk for...
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs ta...
Glioblastoma multiforme (GBM) is one of the most common and deadliest cancers of the central nervous...
Metastasis is an intricate process by which a small number of cancer cells from the primary tumor si...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...