Spectrophotometric determination of norfloxacin using bromophenol blue

AbstractWe reported a spectrophotometric method for the determination of norfloxacin. The method is based on the reaction of the drug with bromophenol blue in acetate buffer at pH 4.1 and measurement of the yellow complex formed at 416nm. Linear calibration graph was obtained from 5 to 150ppm of norfloxacin with percentage relative standard deviation of less than 2% (n=6), the correlation coefficient r=0.9998. The method was applied successfully to drug analysis