IMMUNOHISTOCHEMICAL EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR DOES NOT CORRELATE WITH MICROVESSEL DENSITY IN INVASIVE BLADDER CARCINOMA

Objectives: To investigate the presence or absence of correlation between the immunohistochemical expression of vascular endothelial factor (VEGF) and microvessel density (MVD), and the potential prognostic value patientsin bladder carcinoma. Methods:VEGF expression and MVD wereassessed on specimens from 50 histological confirmed invasive bladder carcinomas. VEGF expression was estimated as 0 –no positive tumor cells, 1 - less than 10% positive tumor cells, 2 – up to 50% positive tumor cells, and 3 – over 50% positive tumor cells.MVD was calculated on slides stained with CD34 antibody. The arithmetical media were statistically processed with SPSS 17.0,Student test and chi square, and p