AbstractIn this paper, we give a more direct proof of the results by Clair and Mokhtari-Sharghi [B. Clair, S. Mokhtari-Sharghi, Zeta functions of discrete groups acting on trees, J. Algebra 237 (2001) 591–620] on the zeta functions of periodic graphs. In particular, using appropriate operator-algebraic techniques, we establish a determinant formula in this context and examine its consequences for the Ihara zeta function. Moreover, we answer in the affirmative one of the questions raised in [R.I. Grigorchuk, A. Żuk, The Ihara zeta function of infinite graphs, the KNS spectral measure and integrable maps, in: V.A. Kaimanovich, et al. (Eds.), Proc. Workshop, Random Walks and Geometry, Vienna, 2001, de Gruyter, Berlin, 2004, pp. 141–180] by Gri...