Toward a Hydrogen Peroxide Sensor for Exhaled Breath Analysis

AbstractIn this contribution a chip-integrated amperometric sensor for the detection of H2O2 in exhaled breath condensate (EBC) is reported. The electrode chip is characterized, and detection of H2O2 in an aqueous phase is shown by means of cyclic voltammetry (CV) and amperometry. Variation of conditions such as the composition of the supporting electrolyte largely influences the obtained electrochemical response. Also it is found that electrochemical pretreatment of the platinum working electrode aiming at surface oxidation improves the detection limit of the sensor. Finally, the device is applied to measurement of H2O2 in the gaseous phase