AbstractACF7 is a member of the spectraplakin family of cytoskeletal crosslinking proteins possessing actin and microtubule binding domains. Here, we show that ACF7 is an essential integrator of MT-actin dynamics. In endodermal cells, ACF7 binds along microtubules but concentrates at their distal ends and at cell borders when polarized. In ACF7's absence, microtubules still bind EB1 and CLIP170, but they no longer grow along polarized actin bundles, nor do they pause and tether to actin-rich cortical sites. The consequences are less stable, long microtubules with skewed cytoplasmic trajectories and altered dynamic instability. In response to wounding, ACF7 null cultures activate polarizing signals, but fail to maintain them and coordinate m...
Cytokinesis requires the proper interactions between microtubules and actin filaments (F-actin) at t...
AbstractBackground: In migrating cells, the retrograde flow of filamentous actin (f-actin) from the ...
Planar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coo...
ACF7 is a member of the spectraplakin family of cytoskeletal crosslinking proteins possessing actin ...
AbstractACF7 is a member of the spectraplakin family of cytoskeletal crosslinking proteins possessin...
SummaryCoordinated interactions between microtubule (MT) and actin cytoskeletons are involved in man...
The dynamic microtubule (MT) and F-actin networks of the cytoskeleton are in constant flux, un...
SummaryHomeostasis and wound healing rely on stem cells (SCs) whose activity and directed migration ...
Spectraplakins are multifunctional proteins that interact with all three types of cytoskeletal filam...
The microtubule cytoskeleton regulates cell polarity by spatially organizing membrane trafficking an...
The microtubule cytoskeleton regulates cell polarity by spatially organizing membrane trafficking an...
In motile fibroblasts, stable microtubules (MTs) are oriented toward the leading edge of cells. How ...
SummaryIn motile fibroblasts, stable microtubules (MTs) are oriented toward the leading edge of cell...
The dynamics of actin and microtubules are coordinated in a variety of cellular and morphogenetic pr...
International audienceThe crosstalk between the actin network and microtubules is essential for cell...
Cytokinesis requires the proper interactions between microtubules and actin filaments (F-actin) at t...
AbstractBackground: In migrating cells, the retrograde flow of filamentous actin (f-actin) from the ...
Planar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coo...
ACF7 is a member of the spectraplakin family of cytoskeletal crosslinking proteins possessing actin ...
AbstractACF7 is a member of the spectraplakin family of cytoskeletal crosslinking proteins possessin...
SummaryCoordinated interactions between microtubule (MT) and actin cytoskeletons are involved in man...
The dynamic microtubule (MT) and F-actin networks of the cytoskeleton are in constant flux, un...
SummaryHomeostasis and wound healing rely on stem cells (SCs) whose activity and directed migration ...
Spectraplakins are multifunctional proteins that interact with all three types of cytoskeletal filam...
The microtubule cytoskeleton regulates cell polarity by spatially organizing membrane trafficking an...
The microtubule cytoskeleton regulates cell polarity by spatially organizing membrane trafficking an...
In motile fibroblasts, stable microtubules (MTs) are oriented toward the leading edge of cells. How ...
SummaryIn motile fibroblasts, stable microtubules (MTs) are oriented toward the leading edge of cell...
The dynamics of actin and microtubules are coordinated in a variety of cellular and morphogenetic pr...
International audienceThe crosstalk between the actin network and microtubules is essential for cell...
Cytokinesis requires the proper interactions between microtubules and actin filaments (F-actin) at t...
AbstractBackground: In migrating cells, the retrograde flow of filamentous actin (f-actin) from the ...
Planar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coo...