AbstractInborn errors of mitochondrial β-oxidation cause ectopic fat accumulation, particularly in the liver. Fatty liver is associated with insulin resistance and predisposes to hepatic fibrosis. The factors underlying the pathophysiological consequences of hepatic fat accumulation have remained poorly defined. Gene expression profiling in a model of acute fatty liver disease induced by blocking long-chain fatty acid β-oxidation was performed to study the early effects of steatosis on the transcriptome. Tetradecylglycidic acid (TDGA) was used to irreversibly inhibit carnitine palmitoyltransferase 1, a key enzyme in the control of mitochondrial β-oxidation. TDGA treatment induced massive microvesicular hepatic steatosis within a 12-h time f...
Accumulation of fat in the liver increases the risk to develop fibrosis and cirrhosis and is associa...
The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for syste...
Non-alcoholic fatty liver disease is a continuum of disorders among which non-alcoholic steatohepati...
Inborn errors of mitochondrial beta-oxidation cause ectopic fat accumulation, particularly in the li...
AbstractInborn errors of mitochondrial β-oxidation cause ectopic fat accumulation, particularly in t...
To extract energy from stored lipids, fatty acids must first be liberated from triglyceride before t...
AIMS/HYPOTHESIS: Complex changes in gene expression are associated with insulin resistance and non-a...
Chronic metabolic overload results in lipid accumulation and subsequent inflammation in white adipos...
Obesity is known to result in insulin resistance, Type 2 diabetes and the eventual development of no...
Obesity frequently leads to insulin resistance and the development of hepatic steatosis. to characte...
We previously demonstrated that high-fat diet (HFD)–induced hepatic lipid accumulation is more sever...
Obesity is a global disorder with multifactorial causes. The liver plays a vital role in fat metabol...
Liver-specific ablation of cytochrome P450 reductase in mice (LCN) results in hepatic steatosis that...
Accumulation of fat in the liver increases the risk to develop fibrosis and cirrhosis and is associa...
BACKGROUND: Chronic metabolic overload results in lipid accumulation and subsequent inflammation in ...
Accumulation of fat in the liver increases the risk to develop fibrosis and cirrhosis and is associa...
The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for syste...
Non-alcoholic fatty liver disease is a continuum of disorders among which non-alcoholic steatohepati...
Inborn errors of mitochondrial beta-oxidation cause ectopic fat accumulation, particularly in the li...
AbstractInborn errors of mitochondrial β-oxidation cause ectopic fat accumulation, particularly in t...
To extract energy from stored lipids, fatty acids must first be liberated from triglyceride before t...
AIMS/HYPOTHESIS: Complex changes in gene expression are associated with insulin resistance and non-a...
Chronic metabolic overload results in lipid accumulation and subsequent inflammation in white adipos...
Obesity is known to result in insulin resistance, Type 2 diabetes and the eventual development of no...
Obesity frequently leads to insulin resistance and the development of hepatic steatosis. to characte...
We previously demonstrated that high-fat diet (HFD)–induced hepatic lipid accumulation is more sever...
Obesity is a global disorder with multifactorial causes. The liver plays a vital role in fat metabol...
Liver-specific ablation of cytochrome P450 reductase in mice (LCN) results in hepatic steatosis that...
Accumulation of fat in the liver increases the risk to develop fibrosis and cirrhosis and is associa...
BACKGROUND: Chronic metabolic overload results in lipid accumulation and subsequent inflammation in ...
Accumulation of fat in the liver increases the risk to develop fibrosis and cirrhosis and is associa...
The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for syste...
Non-alcoholic fatty liver disease is a continuum of disorders among which non-alcoholic steatohepati...