Because of the large number of tests for linkage that are performed in genome scans, the naive estimator of the size of a genetic effect in cases of borderline significance can be inflated and lead to unrealistic expectations for successful replication. As a remedy, this report proposes lower confidence limits that account for the multiple comparisons of the genome scan
An attractive feature of variance-components methods (including the Haseman-Elston tests) for the de...
International audienceIn recent years, a number of large-scale genome-wide association studies have ...
The evaluation of results from primary genomewide linkage scans of complex human traits remains an a...
Because of the large number of tests for linkage that are performed in genome scans, the naive estim...
Abstract Using the simulated data of Problem 2 for Genetic Analysis Workshop 14 (GAW14...
The primary goal of a genomewide scan is to estimate the genomic locations of genes influencing a tr...
The primary goal of a genomewide scan is to estimate the genomic locations of genes influencing a tr...
In modern whole-genome scans, the use of stringent thresholds to control the genome-wide testing err...
In epidemiologic studies on direct genetic associations, hypothesis testing is primarily considered ...
Abstract In high-dimensional studies such as genome-wide association studies, the corr...
Abstract Genome-wide association studies (GWAS) test for disease-trait associations an...
In modern whole-genome scans, the use of stringent thresholds to control the genome-wide testing err...
The interpretation of the results of large association studies encompassing much or all of the human...
<p><b>Copyright information:</b></p><p>Taken from "Resampling methods to reduce the selection bias i...
In this work we show that in genome-wide association studies (GWAS) there is a strong bias favoring ...
An attractive feature of variance-components methods (including the Haseman-Elston tests) for the de...
International audienceIn recent years, a number of large-scale genome-wide association studies have ...
The evaluation of results from primary genomewide linkage scans of complex human traits remains an a...
Because of the large number of tests for linkage that are performed in genome scans, the naive estim...
Abstract Using the simulated data of Problem 2 for Genetic Analysis Workshop 14 (GAW14...
The primary goal of a genomewide scan is to estimate the genomic locations of genes influencing a tr...
The primary goal of a genomewide scan is to estimate the genomic locations of genes influencing a tr...
In modern whole-genome scans, the use of stringent thresholds to control the genome-wide testing err...
In epidemiologic studies on direct genetic associations, hypothesis testing is primarily considered ...
Abstract In high-dimensional studies such as genome-wide association studies, the corr...
Abstract Genome-wide association studies (GWAS) test for disease-trait associations an...
In modern whole-genome scans, the use of stringent thresholds to control the genome-wide testing err...
The interpretation of the results of large association studies encompassing much or all of the human...
<p><b>Copyright information:</b></p><p>Taken from "Resampling methods to reduce the selection bias i...
In this work we show that in genome-wide association studies (GWAS) there is a strong bias favoring ...
An attractive feature of variance-components methods (including the Haseman-Elston tests) for the de...
International audienceIn recent years, a number of large-scale genome-wide association studies have ...
The evaluation of results from primary genomewide linkage scans of complex human traits remains an a...
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