AbstractProtein transduction domains (PTDs) are peptides that afford the internalization of cargo macromolecules (including plasmid DNA, proteins, liposomes, and nanoparticles). In the case of polycationic peptides, the efficiency of PTDs to promote cellular uptake is directly related to their molecular mass or their polyvalent presentation. Similarly, the efficiency of routing to the nucleus increases with the number of nuclear localization signals (NLS) associated with a cargo. The quantitative enhancement, however, depends on the identity of the PTD sequence as well as the targeted cell type. Thus the choice and multivalent presentation of PTD and NLS sequences are important criteria guiding the design of macromolecules intended for spec...
The design of non-viral vectors that efficiently deliver genetic materials into cells, in particular...
SummaryProtein transduction domains (PTDs) are reagents that facilitate the delivery of diverse carg...
The success of nonviral transfection using polymers hinges on efficient nuclear uptake of nucleic ac...
AbstractProtein transduction domains (PTDs) are peptides that afford the internalization of cargo ma...
A cell delivery system is increasing in use in many areas of cell and molecular biology and bio-medi...
The lipid bilayer of a cell presents a significant barrier for the delivery of many molecular imagin...
Transfection reagents are used to deliver DNA and siRNA into cells to achieve genetic manipulations,...
AbstractThe cellular delivery of therapeutic agents and their localization within cells is currently...
Currently, most of the commercially available therapeutics are all targeting cell surface receptors ...
Cell penetrating peptides (CPP), also known as protein transduction domains (PTD), are small peptide...
Currently, most of the commercially available therapeutics are all targeting cell surface receptors ...
The ability of nonviral gene delivery systems to overcome extracellular and intracellular barriers i...
Proteins are primary targets in drug discovery. However, with a few rare exceptions, they are unable...
Statement of Purpose: The field of non-viral gene delivery has developed many sophisticated approach...
The ultimate destination for most gene therapy vectors is the nucleus and nuclear import of potentia...
The design of non-viral vectors that efficiently deliver genetic materials into cells, in particular...
SummaryProtein transduction domains (PTDs) are reagents that facilitate the delivery of diverse carg...
The success of nonviral transfection using polymers hinges on efficient nuclear uptake of nucleic ac...
AbstractProtein transduction domains (PTDs) are peptides that afford the internalization of cargo ma...
A cell delivery system is increasing in use in many areas of cell and molecular biology and bio-medi...
The lipid bilayer of a cell presents a significant barrier for the delivery of many molecular imagin...
Transfection reagents are used to deliver DNA and siRNA into cells to achieve genetic manipulations,...
AbstractThe cellular delivery of therapeutic agents and their localization within cells is currently...
Currently, most of the commercially available therapeutics are all targeting cell surface receptors ...
Cell penetrating peptides (CPP), also known as protein transduction domains (PTD), are small peptide...
Currently, most of the commercially available therapeutics are all targeting cell surface receptors ...
The ability of nonviral gene delivery systems to overcome extracellular and intracellular barriers i...
Proteins are primary targets in drug discovery. However, with a few rare exceptions, they are unable...
Statement of Purpose: The field of non-viral gene delivery has developed many sophisticated approach...
The ultimate destination for most gene therapy vectors is the nucleus and nuclear import of potentia...
The design of non-viral vectors that efficiently deliver genetic materials into cells, in particular...
SummaryProtein transduction domains (PTDs) are reagents that facilitate the delivery of diverse carg...
The success of nonviral transfection using polymers hinges on efficient nuclear uptake of nucleic ac...