Blood Clot Formation under Flow: The Importance of Factor XI Depends Strongly on Platelet Count

Fogelson, Aaron L.
Hussain, Yasmeen H.
Leiderman, Karin

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Publication date

January 2012

DOI

10.1016/j.bpj.2011.10.048

Publisher

Biophysical Society. Published by Elsevier Inc.

Abstract

AbstractA previously validated mathematical model of intravascular platelet deposition and tissue factor (TF)-initiated coagulation under flow is extended and used to assess the influence on thrombin production of the activation of factor XI (fXI) by thrombin and of the activation of factor IX (fIX) by fXIa. It is found that the importance of the thrombin-fXIa-fIXa feedback loop to robust thrombin production depends on the concentration of platelets in the blood near the injury. At a near-wall platelet concentration of ∼250,000/μL, typical in vessels in which the shear rate is <200 s−1, thrombin activation of fXI makes a significant difference only at low densities of exposed TF. If the near-wall platelet concentration is significantly high...

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Blood Clot Formation under Flow: The Importance of Factor XI Depends Strongly on Platelet Count

Abstract

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Blood Clot Formation under Flow: The Importance of Factor XI Depends Strongly on Platelet Count

Abstract

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