AbstractObjective: Articular cartilage has only limited capacities for repair and it is not known what is the exact mechanism of matrix restoration. It was investigated whether the reparative process in murine articular cartilage after moderate proteoglycan depletion is accompanied by a change in the chondrocyte phenotype either to hypertrophy or to a less differentiated phenotype as assayed by the expression of specific collagen subtypes.Design: Moderate proteoglycan depletion was induced by injection of papain whereafter the expression of collagen type I mRNA, collagen IIA and IIB mRNA and type X collagen mRNA in patellar cartilage, as markers for chondrocyte phenotype, was investigated by RT-PCR during normal cartilage physiology and mat...
AbstractObjective The STR/ort mouse develops a naturally occurring osteoarthritis of the femorotibia...
Note:A major limitation in analyzing collagen degradation in articular cartilage in arthritis has be...
Articular cartilage destruction and loss of function in arthritic diseases involves proteolytic degr...
Objective - To evaluate the influence of inactivation of one allele ("heterozygous knockout" or "het...
Objective: The STR/ort mouse strain develops osteoarthritis (OA) of the medial tibial cartilage whil...
Adult articular cartilage synthesises very little type II collagen in comparison to young cartilage....
Adult articular cartilage synthesises very little type II collagen in comparison to young cartilage....
AbstractObjective To investigate whether the development of osteoarthritic lesions in the knee joint...
Adult articular cartilage by dry weight is two-thirds collagen. The collagen has a unique molecular ...
AbstractObjective The STR/ort mouse strain develops osteoarthritis (OA) of the medial tibial cartila...
SummaryObjectivesJoint degeneration in osteoarthritis (OA) is characterised by damage and loss of ar...
AbstractThis study has assessed the relative proportions of type I and II collagens and IIA procolla...
AbstractObjective: To determine in articular cartilage whether degraded type II collagen is more abu...
The in vivo role of the extracellular matrix and the manner in which it interfaces with soluble regu...
Item does not contain fulltextOBJECTIVE: To investigate whether the development of osteoarthritic le...
AbstractObjective The STR/ort mouse develops a naturally occurring osteoarthritis of the femorotibia...
Note:A major limitation in analyzing collagen degradation in articular cartilage in arthritis has be...
Articular cartilage destruction and loss of function in arthritic diseases involves proteolytic degr...
Objective - To evaluate the influence of inactivation of one allele ("heterozygous knockout" or "het...
Objective: The STR/ort mouse strain develops osteoarthritis (OA) of the medial tibial cartilage whil...
Adult articular cartilage synthesises very little type II collagen in comparison to young cartilage....
Adult articular cartilage synthesises very little type II collagen in comparison to young cartilage....
AbstractObjective To investigate whether the development of osteoarthritic lesions in the knee joint...
Adult articular cartilage by dry weight is two-thirds collagen. The collagen has a unique molecular ...
AbstractObjective The STR/ort mouse strain develops osteoarthritis (OA) of the medial tibial cartila...
SummaryObjectivesJoint degeneration in osteoarthritis (OA) is characterised by damage and loss of ar...
AbstractThis study has assessed the relative proportions of type I and II collagens and IIA procolla...
AbstractObjective: To determine in articular cartilage whether degraded type II collagen is more abu...
The in vivo role of the extracellular matrix and the manner in which it interfaces with soluble regu...
Item does not contain fulltextOBJECTIVE: To investigate whether the development of osteoarthritic le...
AbstractObjective The STR/ort mouse develops a naturally occurring osteoarthritis of the femorotibia...
Note:A major limitation in analyzing collagen degradation in articular cartilage in arthritis has be...
Articular cartilage destruction and loss of function in arthritic diseases involves proteolytic degr...