AbstractCalcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calcium release. Buffer-mediated calcium diffusion in the cytosol plays a crucial role in the process. However, most models of calcium waves either treat buffers phenomenologically or assume that they are in equilibrium with calcium (the rapid buffering approximation). In this article we address the issue of whether this approximation provides a good description of wave propagation. We first compare the timescales present in the problem, and determine the situations in which the equilibrium hypothesis fails. We then present a series of numerical studies based on the simple fire-diffuse-fire model of wave propagation. We find that the differ...
The functional properties of inositol(1,4,5)-triphosphate (IP3) receptors allow a variety of intrace...
We present a theoretical analysis of intracellular calcium waves propagated by calcium feedback at t...
AbstractPunctate releases of Ca2+, called Ca2+ sparks, originate at the regular array of t-tubules i...
Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calciu...
AbstractCalcium waves propagate inside cells due to a regenerative mechanism known as calcium-induce...
Chemical reaction and diffusion are important phenomena in quantitative neurobiology and biophysics....
Chemical reaction and diffusion are important phenomena in quantitative neurobiology and biophysics....
The fire-diffuse-fire model provides an idealized model of Ca2+ release within living cells. The eff...
In many types of eukaryotic cells, the activation of surface receptors leads to the production of in...
AbstractIntercellular regenerative calcium waves in systems such as the liver and the blowfly saliva...
Although the exact details are disputed, it is well established that propagating waves of increased ...
In the presence of rapid buffers the full reaction-diffusion equations describing Ca2+ transport can...
Based on realistic mechanisms of Ca2+ buffering that include both stationary and mobile buffers, we ...
Atrial myocytes in a number of species lack transverse tubules. As a consequence the intracellular c...
We present a bidomain fire-diffuse-fire model that facilitates mathematical analysis of propagating ...
The functional properties of inositol(1,4,5)-triphosphate (IP3) receptors allow a variety of intrace...
We present a theoretical analysis of intracellular calcium waves propagated by calcium feedback at t...
AbstractPunctate releases of Ca2+, called Ca2+ sparks, originate at the regular array of t-tubules i...
Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calciu...
AbstractCalcium waves propagate inside cells due to a regenerative mechanism known as calcium-induce...
Chemical reaction and diffusion are important phenomena in quantitative neurobiology and biophysics....
Chemical reaction and diffusion are important phenomena in quantitative neurobiology and biophysics....
The fire-diffuse-fire model provides an idealized model of Ca2+ release within living cells. The eff...
In many types of eukaryotic cells, the activation of surface receptors leads to the production of in...
AbstractIntercellular regenerative calcium waves in systems such as the liver and the blowfly saliva...
Although the exact details are disputed, it is well established that propagating waves of increased ...
In the presence of rapid buffers the full reaction-diffusion equations describing Ca2+ transport can...
Based on realistic mechanisms of Ca2+ buffering that include both stationary and mobile buffers, we ...
Atrial myocytes in a number of species lack transverse tubules. As a consequence the intracellular c...
We present a bidomain fire-diffuse-fire model that facilitates mathematical analysis of propagating ...
The functional properties of inositol(1,4,5)-triphosphate (IP3) receptors allow a variety of intrace...
We present a theoretical analysis of intracellular calcium waves propagated by calcium feedback at t...
AbstractPunctate releases of Ca2+, called Ca2+ sparks, originate at the regular array of t-tubules i...