Nephritogenic cytokines and disease in MRL-Faslpr kidneys are dependent on multiple T-cell subsets.BackgroundRenal parenchymal cells produce cytokines, colony-stimulating factor-1 (CSF-1), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α), which recruit autoreactive T cells and, in turn, elicit renal injury in MRL-Faslpr mice.MethodsTo determine whether select T-cell populations regulate intrarenal nephritogenic cytokines (CSF-1, GM-CSF, and TNF-α) and renal disease, we compared MRL-Faslpr mice that are genetically deficient in T-cell receptor (TCR) αßbgr; T cells, CD4 T cells, and major histocompatibility complex class I (MHC class I), lacking CD8 and double negative (DN) T cells, with wild-type...
The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic in...
MRL/Mp-lpr/lpr (MRL-lpr) mice develop an aggressive autoimmune disorder characterized by arthritis, ...
Because TNF and IL-1 can initiate immunologic and inflammatory events alone or synergistically, a lo...
Nephritogenic cytokines and disease in MRL-Faslpr kidneys are dependent on multiple T-cell subsets.B...
Systemic autoimmune nephritogenic components induce CSF-1 and TNF-α in MRL kidneys. MKL-Faslpr mice ...
Infiltrating macrophages and T cells are instrumental in autoimmune kidney destruction of MRL-Faslpr...
In systemic lupus erythematosus, CD4+ T cells play key roles in the initiation and promotion of auto...
Regulatory interactions of αβ and γλ T cells in glomerulonephritis.BackgroundSeveral lines of eviden...
The progression of kidney disease to renal failure correlates with infiltration of mononuclear immun...
Despite glomerulonephritis being an immune-mediated disease, the contributions of individual immune ...
Autoimmunity against the Goodpasture antigen α3IV-NC1 results in antiglomerular basement membrane gl...
Heterogeneous T cell receptor Vβ gene repertoire in murine interstitial nephritis. Anti-tubular base...
Anti-myeloperoxidase nephritogenic autoimmunity induces severe glomerulonephritis. To assess the the...
Biphasic increase in circulating and renal TNF-α in MRL-lpr mice with differing regulatory mechanism...
Autoreactive kidney-infiltrating T-cell clones in murine lupus nephritis. T-cells have been implicat...
The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic in...
MRL/Mp-lpr/lpr (MRL-lpr) mice develop an aggressive autoimmune disorder characterized by arthritis, ...
Because TNF and IL-1 can initiate immunologic and inflammatory events alone or synergistically, a lo...
Nephritogenic cytokines and disease in MRL-Faslpr kidneys are dependent on multiple T-cell subsets.B...
Systemic autoimmune nephritogenic components induce CSF-1 and TNF-α in MRL kidneys. MKL-Faslpr mice ...
Infiltrating macrophages and T cells are instrumental in autoimmune kidney destruction of MRL-Faslpr...
In systemic lupus erythematosus, CD4+ T cells play key roles in the initiation and promotion of auto...
Regulatory interactions of αβ and γλ T cells in glomerulonephritis.BackgroundSeveral lines of eviden...
The progression of kidney disease to renal failure correlates with infiltration of mononuclear immun...
Despite glomerulonephritis being an immune-mediated disease, the contributions of individual immune ...
Autoimmunity against the Goodpasture antigen α3IV-NC1 results in antiglomerular basement membrane gl...
Heterogeneous T cell receptor Vβ gene repertoire in murine interstitial nephritis. Anti-tubular base...
Anti-myeloperoxidase nephritogenic autoimmunity induces severe glomerulonephritis. To assess the the...
Biphasic increase in circulating and renal TNF-α in MRL-lpr mice with differing regulatory mechanism...
Autoreactive kidney-infiltrating T-cell clones in murine lupus nephritis. T-cells have been implicat...
The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic in...
MRL/Mp-lpr/lpr (MRL-lpr) mice develop an aggressive autoimmune disorder characterized by arthritis, ...
Because TNF and IL-1 can initiate immunologic and inflammatory events alone or synergistically, a lo...