SummaryA major current deficit in structural biology is the lack of high-resolution structures of eukaryotic membrane proteins, many of which are key drug targets for the treatment of disease. Numerous eukaryotic membrane proteins require specific lipids for their stability and activity, and efforts to crystallize and solve the structures of membrane proteins that do not address the issue of lipids frequently end in failure rather than success. To help address this problem, we have developed a sparse matrix crystallization screen consisting of 48 lipidic-sponge phase conditions. Sponge phases form liquid lipid bilayer environments which are suitable for conventional hanging- and sitting-drop crystallization experiments. Using the sponge pha...
peer-reviewedThis paper was obtained through PEER (Publishing and the Ecology of European Research) ...
AbstractCrystals of transmembrane proteins may be grown from detergent solutions or in a matrix of m...
ABSTRACT Hydrated monoolein forms the cubic-Pn3m mesophase that has been used for in meso crystalliz...
A major current deficit in structural biology is the lack of high-resolution structures of eukaryoti...
Membrane proteins carry out many essential tasks in cells such as signaling and transport, or functi...
Bicontinuous lipidic cubic phases can be used as a host for growing crystals of membrane proteins. S...
Membrane proteins are involved in many important biological processes and in order to understand the...
Membrane protein structural biology is enjoying a steady acceleration in the rate of success. Nevert...
Membrane proteins perform critical functions in living cells related to signal transduction, transpo...
The need for high-resolution structure information on membrane proteins is immediate and growing. Cu...
The crystallization of membrane proteins in amphiphile-rich materials such as lipidic cubic phases i...
The in meso technique of membrane protein crystallization has been successfully used to crystallize ...
Obtaining well-diffracting crystals of membrane proteins, which is crucial to the molecular-level un...
AbstractDue to the difficulty to crystallize membrane proteins, there is a considerable interest to ...
With the recent developments in the field of free electron laser based serial femtosecond crystallog...
peer-reviewedThis paper was obtained through PEER (Publishing and the Ecology of European Research) ...
AbstractCrystals of transmembrane proteins may be grown from detergent solutions or in a matrix of m...
ABSTRACT Hydrated monoolein forms the cubic-Pn3m mesophase that has been used for in meso crystalliz...
A major current deficit in structural biology is the lack of high-resolution structures of eukaryoti...
Membrane proteins carry out many essential tasks in cells such as signaling and transport, or functi...
Bicontinuous lipidic cubic phases can be used as a host for growing crystals of membrane proteins. S...
Membrane proteins are involved in many important biological processes and in order to understand the...
Membrane protein structural biology is enjoying a steady acceleration in the rate of success. Nevert...
Membrane proteins perform critical functions in living cells related to signal transduction, transpo...
The need for high-resolution structure information on membrane proteins is immediate and growing. Cu...
The crystallization of membrane proteins in amphiphile-rich materials such as lipidic cubic phases i...
The in meso technique of membrane protein crystallization has been successfully used to crystallize ...
Obtaining well-diffracting crystals of membrane proteins, which is crucial to the molecular-level un...
AbstractDue to the difficulty to crystallize membrane proteins, there is a considerable interest to ...
With the recent developments in the field of free electron laser based serial femtosecond crystallog...
peer-reviewedThis paper was obtained through PEER (Publishing and the Ecology of European Research) ...
AbstractCrystals of transmembrane proteins may be grown from detergent solutions or in a matrix of m...
ABSTRACT Hydrated monoolein forms the cubic-Pn3m mesophase that has been used for in meso crystalliz...