Striatal transcriptome analysis of a congenic mouse line (chromosome 11: 50–60Mb) exhibiting reduced methamphetamine sensitivity

Yazdani, Neema
Shen, Ying
Johnson, W. Evan
Bryant, Camron D.

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Publication date

June 2016

DOI

10.1016/j.gdata.2016.03.009

Publisher

The Authors. Published by Elsevier Inc.

Abstract

AbstractAddiction to psychostimulants such as Methamphetamine (MA) is a significant public health issue in the United States and currently, there are no FDA approved pharmacological interventions. Previously, using short term-selected mouse lines for high and low MA sensitivity that were derived from an F2 cross between C57BL/6J (B6) and DBA/2J (D2) strains, we identified a quantitative trait locus (QTL) on chromosome (chr) 11 that influenced sensitivity to MA-induced locomotor activity (D2<B6). Using interval-specific murine congenic lines containing various D2 allelic segments on a B6 background, we fine mapped the QTL to a 206kb critical interval on chromosome 11. To investigate the neurobiological mechanism by which this QTL decreases M...

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Striatal transcriptome analysis of a congenic mouse line (chromosome 11: 50–60Mb) exhibiting reduced methamphetamine sensitivity

Abstract

Extracted data

Striatal transcriptome analysis of a congenic mouse line (chromosome 11: 50–60Mb) exhibiting reduced methamphetamine sensitivity

Abstract

Extracted data

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