119 Importance of left ventricular remodelling and regional function in the occurrence of ischemic mitral regurgitation

IntroductionMitral regurgitation developing in the course of myocardial infarction significantly worsens survival. The aim of this study is to determine the relative importance of the global and regional left ventricular (LV) remodelling in the occurrence of ischemic mitral regurgitation (IMR).Methods81 patients (mean age=61±11 years) admitted with acute myocardial infarction (AMI) were screened. Patients with atrial fibrillation and organic valvular diseases were excluded from the study. Echocardiography (two-dimensional and Doppler echocardiograms) was performed in the first week after admission. The 81 patients were divided in 2 groups: with IMR (group1=39 patients) and without IMR (group2=42 patients). LV volumes were calculated by apical biplane Simpson's rule. The LV wall-motion score (WMS) index was obtained in a 17 segment model according to established methods. To identify the influence of regional wall-motion impairment for each individual LV segment, the mean WMS was calculated for each segment and compared between the 2 groups.ResultsThe echocardiographic parameters that were associated with IMR were: LV dilatation and sphericity (p<0,0001), reduced ejection fraction (p<0,0001), inferior (p