Anticonvulsant Effect of Berberis integerrima L. Root Extracts in Mice

AbstractBerberis integerrima is a member of Berberidaceae family. Berberine is one of the main constituents of this plant, having neuroprotective effect on central nervous system diseases. In this study, the anticonvulsant activity of methanolic extract, and hydromethanolic fraction, and chloroform fraction of B integerrima was assessed. The anticonvulsant effect of B integerrima was investigated using both pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizure models. The LD50 value of the methanolic extract was 302.676mg/kg. In the PTZ test, methanolic extract (140 and 200mg/kg, i.p., p<0.01), hydromethanolic fraction (200mg/kg, p<0.01), and chloroform fraction (200mg/kg, p