The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. [1] present novel compounds, completely selective for MMP-13, with a unique binding mode
SThe matrix metalloproteinase (MMP) family has been a pharmaceutical target for over 20 years. Despi...
Matrix metalloproteinases (MMPs) contribute to many physiological and pathological phenomena via the...
Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endoproteases known to exert m...
The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc...
SummaryInhibitors for matrix metalloproteinases (MMPs) are under investigation for the treatment of ...
Matrix metalloproteinases (MMPs) are a class of zinc dependent endopeptidases which play a crucial r...
Matrix metalloproteinases (MMPs) are zinc enzymes responsible for the degradation of the extracellul...
A new class of potent matrix metalloproteinase (MMP) inhibitors designed by structure-based optimiza...
We describe the use of comparative structural analysis and structure-guided molecular design to deve...
AbstractThis short review highlights some recent advances in matrix metalloproteinase inhibitor (MMP...
The matrix metalloproteinases (MMPs) exhibit a broad array of activities, some catalytic and some no...
The development of matrix metalloproteinase (MMP) inhibitors has often been frustrated by a lack of ...
Drug candidates against matrix metalloproteinases (MMPs) failed in the clinic in the past because t...
The development of novel and selective full-length inhibitors against medicinally relevant zinc meta...
Matrix metalloproteinases (MMPs) are zinc-dependent enzymes involved in several pathological states...
SThe matrix metalloproteinase (MMP) family has been a pharmaceutical target for over 20 years. Despi...
Matrix metalloproteinases (MMPs) contribute to many physiological and pathological phenomena via the...
Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endoproteases known to exert m...
The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc...
SummaryInhibitors for matrix metalloproteinases (MMPs) are under investigation for the treatment of ...
Matrix metalloproteinases (MMPs) are a class of zinc dependent endopeptidases which play a crucial r...
Matrix metalloproteinases (MMPs) are zinc enzymes responsible for the degradation of the extracellul...
A new class of potent matrix metalloproteinase (MMP) inhibitors designed by structure-based optimiza...
We describe the use of comparative structural analysis and structure-guided molecular design to deve...
AbstractThis short review highlights some recent advances in matrix metalloproteinase inhibitor (MMP...
The matrix metalloproteinases (MMPs) exhibit a broad array of activities, some catalytic and some no...
The development of matrix metalloproteinase (MMP) inhibitors has often been frustrated by a lack of ...
Drug candidates against matrix metalloproteinases (MMPs) failed in the clinic in the past because t...
The development of novel and selective full-length inhibitors against medicinally relevant zinc meta...
Matrix metalloproteinases (MMPs) are zinc-dependent enzymes involved in several pathological states...
SThe matrix metalloproteinase (MMP) family has been a pharmaceutical target for over 20 years. Despi...
Matrix metalloproteinases (MMPs) contribute to many physiological and pathological phenomena via the...
Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endoproteases known to exert m...
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