Phosphatidylcholine multilayers, containing 20% water by total sample weight and gramicidin/lipid molar ratios up to 1:40 were aligned by low temperature annealing (less than 60 degrees C) and mechanical stressing. We were able to obtain large (greater than 80 micron thick X 40 mm2 area) monodomain defect-free multilayers containing approximately 10(17) uniformly oriented gramicidin channels. The alignment of lipid multilayers was monitored by conoscopy and polarized microscopy. The smectic defects, which appeared during the alignment process, were identified and dissolved. The incorporation of gramicidin into the multilayers in the form of transmembrane channels was indicated by its circular dichroic (CD) spectrum. A well-defined CD spectr...
31P NMR spectroscopy and optical microscopy have been used to characterize samples of gramicidin D i...
Solid-state nuclear magnetic resonance (NMR) measurements on 13C-labeled analogues of the ion channe...
Membrane-spanning gramicidin channels remain unique because of their small size, well-characterized ...
Phosphatidylcholine multilayers, containing 20% water by total sample weight and gramicidin/lipid mo...
Phosphatidylcholine multilayers containing $\sim$24% water by total sample weight and gramicidin/lip...
Supported membranes on polymer cushions are of fundamental interest as models for cell membranes. Th...
AbstractGramicidin is an antibiotic peptide that can be incorporated into the monolayers of cell mem...
The membrane structure of the naturally occurring gramicidins A, B, and C was investigated using cir...
AbstractThe matching of hydrophobic lengths of integral membrane proteins and the surrounding lipid ...
X-ray diffraction has been applied in measuring the helical pitch of the gramicidin channel in orien...
Gramicidin A, a hydrophobic linear polypeptide, forms channels in phospholipid membranes that are sp...
The molecular structure of channels formed by gramicidin A in a lipid membrane was imaged by a scann...
AbstractAlthough there have been several decades of literature illustrating the opening and closing ...
Membrane channels facilitate the flow of ions across biological membranes, a process which is import...
Polarized infrared spectroscopy has been used to investigate the orientation of gramicidin A incorpo...
31P NMR spectroscopy and optical microscopy have been used to characterize samples of gramicidin D i...
Solid-state nuclear magnetic resonance (NMR) measurements on 13C-labeled analogues of the ion channe...
Membrane-spanning gramicidin channels remain unique because of their small size, well-characterized ...
Phosphatidylcholine multilayers, containing 20% water by total sample weight and gramicidin/lipid mo...
Phosphatidylcholine multilayers containing $\sim$24% water by total sample weight and gramicidin/lip...
Supported membranes on polymer cushions are of fundamental interest as models for cell membranes. Th...
AbstractGramicidin is an antibiotic peptide that can be incorporated into the monolayers of cell mem...
The membrane structure of the naturally occurring gramicidins A, B, and C was investigated using cir...
AbstractThe matching of hydrophobic lengths of integral membrane proteins and the surrounding lipid ...
X-ray diffraction has been applied in measuring the helical pitch of the gramicidin channel in orien...
Gramicidin A, a hydrophobic linear polypeptide, forms channels in phospholipid membranes that are sp...
The molecular structure of channels formed by gramicidin A in a lipid membrane was imaged by a scann...
AbstractAlthough there have been several decades of literature illustrating the opening and closing ...
Membrane channels facilitate the flow of ions across biological membranes, a process which is import...
Polarized infrared spectroscopy has been used to investigate the orientation of gramicidin A incorpo...
31P NMR spectroscopy and optical microscopy have been used to characterize samples of gramicidin D i...
Solid-state nuclear magnetic resonance (NMR) measurements on 13C-labeled analogues of the ion channe...
Membrane-spanning gramicidin channels remain unique because of their small size, well-characterized ...