AbstractThe Herpes Simplex Virus thymidine kinase (HSV-tk) suicide gene/ganciclovir (GCV) approach has been used for the treatment of a variety of cancers. The purpose of the present study was to evaluate the cytotoxic effect of ganciclovir in oral squamous cancer cells, previously transfected with HSV-tk gene delivered by transferrin-associated complexes (Tf-lipoplexes), as well as to investigate the mechanisms involved in the bystander effect and in the process of cell death. The delivery of HSV-tk gene to the oral cancer cells, HSC-3 and SCC-7, mediated by Tf-lipoplexes followed by ganciclovir treatment resulted in essentially 100% cytotoxicity, the observed toxic effect being dependent both on GCV dose and incubation time. Cell death wa...
Objectives: Oral Squamous Cell carcinoma (OSCC) is the most prevalent cancer involving the oral cavi...
At the fore-front of cancer research, gene therapy offers the potential to either promote cell death...
Background: The inefficiency of herpes simplex virus thymidine kinase (TK) gene transfer and toxicit...
The Herpes Simplex Virus thymidine kinase (HSV-tk) suicide gene/ganciclovir (GCV) approach has been ...
AbstractThe Herpes Simplex Virus thymidine kinase (HSV-tk) suicide gene/ganciclovir (GCV) approach h...
Suicide gene therapy has been used for the treatment of a variety of cancers. We reported previously...
The tumoricidal effect of herpes simplex virus thymidine kinase (HSV-tk) gene transfer followed by g...
Oral squamous cell carcinoma (OSCC) is a well-diagnosed epithelial malady with a high rate of morbid...
INTRODUCTION: Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-tk/GCV)-induced suicide gene th...
We report virus-free transfer of a "suicide" gene into tumoral cells. The system can be used in vitr...
Because it appears impossible to transfer a suicide gene to all the cells of a cancer, existence of...
At the fore-front of cancer research, gene therapy offers the potential to either promote cell death...
A promising new approach for the gene therapy of cancer is the introduction of the herpes simplex vi...
Despite the development of new therapeutic strategies, cancer remains incurable in most patients wit...
The herpes simplex virus thymidine kinase/gancyclovir (HSV-tk/GCV) system is studied as cytotoxic li...
Objectives: Oral Squamous Cell carcinoma (OSCC) is the most prevalent cancer involving the oral cavi...
At the fore-front of cancer research, gene therapy offers the potential to either promote cell death...
Background: The inefficiency of herpes simplex virus thymidine kinase (TK) gene transfer and toxicit...
The Herpes Simplex Virus thymidine kinase (HSV-tk) suicide gene/ganciclovir (GCV) approach has been ...
AbstractThe Herpes Simplex Virus thymidine kinase (HSV-tk) suicide gene/ganciclovir (GCV) approach h...
Suicide gene therapy has been used for the treatment of a variety of cancers. We reported previously...
The tumoricidal effect of herpes simplex virus thymidine kinase (HSV-tk) gene transfer followed by g...
Oral squamous cell carcinoma (OSCC) is a well-diagnosed epithelial malady with a high rate of morbid...
INTRODUCTION: Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-tk/GCV)-induced suicide gene th...
We report virus-free transfer of a "suicide" gene into tumoral cells. The system can be used in vitr...
Because it appears impossible to transfer a suicide gene to all the cells of a cancer, existence of...
At the fore-front of cancer research, gene therapy offers the potential to either promote cell death...
A promising new approach for the gene therapy of cancer is the introduction of the herpes simplex vi...
Despite the development of new therapeutic strategies, cancer remains incurable in most patients wit...
The herpes simplex virus thymidine kinase/gancyclovir (HSV-tk/GCV) system is studied as cytotoxic li...
Objectives: Oral Squamous Cell carcinoma (OSCC) is the most prevalent cancer involving the oral cavi...
At the fore-front of cancer research, gene therapy offers the potential to either promote cell death...
Background: The inefficiency of herpes simplex virus thymidine kinase (TK) gene transfer and toxicit...