Anti-arthritic effects of microneedling with bee venom gel

AbstractObjectiveTo combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel.MethodsIn this study, the sodium urate and LPS were used on rats and mice to construct the model. Bee venom gel–microneedle combination effect on the model is to determine the role of microneedle gel permeation by observing inflammation factors.ResultsCompared with the model group, the Bee venom gel–microneedle combination group can reduce the level of Serum NO of the acute gouty inflammation model caused by sodium urate, and on LPS induced mouse model of acute inflammation effect and the micro.ConclusionsBee venom can significantly suppress the occurrence of gouty arthritis inflammation in rats and mice LPS inflammatory reaction. Choose the 750 μm microneedle with 10N force on skin about 3 min, bee venom can play the biggest role, and the anti-inflammatory effect is obvious, Microneedles can promote the percutaneous absorption of the active macromolecules bee venom gel