Hypoxia and interleukin-1β stimulate vascular endothelial growth factor production in human proximal tubular cells.BackgroundVascular endothelial growth factor (VEGF) promotes angiogenesis and inflammatory reactions. VEGF mRNA is detectable in the proximal tubules of inflamed kidneys but not in normals. In other organs VEGF gene expression is induced by hypoxia and cytokines such as interleukin 1 (IL-1). To identify the cellular mechanisms in control of tubular VEGF production, we studied effects of hypoxia and IL-1β in VEGF mRNA levels, VEGF secretion, and activity of the hypoxia-inducible dimeric transcription factor 1 (HIF-1α/β) in human proximal tubular epithelial cells (PTECs) in primary culture.MethodsPTECs were grown in monolayers fr...
Effects of hypoxia on renal growth factor expression in the rat kidney. There is accumulating eviden...
Activated hepatic stellate cells (HSCs) produce cyclooxygenase-2 (COX-2) protein to induce vascular ...
The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not b...
Hypoxia and interleukin-1β stimulate vascular endothelial growth factor production in human proximal...
Redistribution of cytoplasmic VEGF to the basolateral aspect of renal tubular cells in ischemia-repe...
ABSTRACT Low oxygen tension (hypoxia) is a major inducer of neovascularisation and evidence emergin...
Early kidney development is associated with the coordinated branching of the renal tubular and vascu...
Hypoxia is an important regulator of vascular endothelial growth factor (VEGF) expression, and VEGF ...
erodimer comprising the oxygen-regulated subunit, HIF-1, and HIF-1, mediates transcription of the ge...
The presence of hypoxia in tumor and its role in promoting angiogenesis are well-established. Recent...
BackgroundHypoxia contributes to a cascade of inflammatory response mechanisms in kidneys that resul...
During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the...
During short-term hypoxia, Hypoxia Inducible Factors (particular their subunits HIF-1α and HIF-2α) r...
Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis and vascular protect...
AbstractTo determine whether low oxygen is a stimulus for endothelial cell differentiation and vascu...
Effects of hypoxia on renal growth factor expression in the rat kidney. There is accumulating eviden...
Activated hepatic stellate cells (HSCs) produce cyclooxygenase-2 (COX-2) protein to induce vascular ...
The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not b...
Hypoxia and interleukin-1β stimulate vascular endothelial growth factor production in human proximal...
Redistribution of cytoplasmic VEGF to the basolateral aspect of renal tubular cells in ischemia-repe...
ABSTRACT Low oxygen tension (hypoxia) is a major inducer of neovascularisation and evidence emergin...
Early kidney development is associated with the coordinated branching of the renal tubular and vascu...
Hypoxia is an important regulator of vascular endothelial growth factor (VEGF) expression, and VEGF ...
erodimer comprising the oxygen-regulated subunit, HIF-1, and HIF-1, mediates transcription of the ge...
The presence of hypoxia in tumor and its role in promoting angiogenesis are well-established. Recent...
BackgroundHypoxia contributes to a cascade of inflammatory response mechanisms in kidneys that resul...
During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the...
During short-term hypoxia, Hypoxia Inducible Factors (particular their subunits HIF-1α and HIF-2α) r...
Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis and vascular protect...
AbstractTo determine whether low oxygen is a stimulus for endothelial cell differentiation and vascu...
Effects of hypoxia on renal growth factor expression in the rat kidney. There is accumulating eviden...
Activated hepatic stellate cells (HSCs) produce cyclooxygenase-2 (COX-2) protein to induce vascular ...
The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not b...