Hepatitis E prevalence among HIV infected patients with elevated liver enzymes in the Netherlands

Hassing, R.J.
van der Eijk, A.A.
Lopes, V. Baptista
Snijdewind, I.J.
de Man, R.A.
Pas, S.D.
van der Ende, M.E.

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Publication date

August 2014

DOI

10.1016/j.jcv.2014.05.009

Publisher

Elsevier B.V.

Abstract

AbstractBackgroundIn recent years chronic hepatitis E virus (HEV) infections have been reported in immunosuppressed patients, including HIV-positive patients with low CD4 cell counts. Because of delayed anti-HEV seroconversion in patients with CD4 cell count<200cells/ml it is difficult to draw firm conclusions on HEV-seroprevalence in a population of HIV positive patients.ObjectivesTo determine the HEV seroprevalence in a population of HIV infected patients.Study designWe retrospectively analysed the HEV prevalence in a population of 256 HIV infected patients with liver enzyme elevations (LEEs), using HEV specific antibody testing and HEV-RNA detection.ResultsWithin this cohort we observed a HEV-seroprevalence of 11.7%, without any anti-HEV...