Canonical Wnt signals are important for activation of epithelial skin stem cells, but the role of individual Wnt ligands remains uncertain. Ouji et al. demonstrate a key role for Wnt-3a in partial maintenance and long-term expansion of epithelial skin stem cells in vitro. They also report a method for expanding these cells in vitro without feeder cells
SummaryWnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of W...
The term "Wnt signaling" does not refer to one uniform signal transduction cascade. Instead, it desc...
β-Catenin, a key transducer molecule of Wnt signaling, is required for adult hair follicle growth an...
Although previous reports suggested that canonical Wnt signaling has opposing effects on epidermal a...
CD49f+CD34+ cells, a skin epithelial stem cell (EpSC)-rich population, were prepared from adult mous...
Canonical Wnt signaling support the formation and maintenance of stem and cancer stem cells. Recent ...
The adult human body is built of around 3.72 × 1013 cells. These cells display a great variation in ...
The skin is a classical example of a tissue maintained by stem cells. However, the identity of the s...
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution...
PurposeA chemical approach to examine the role of Wnt signaling in maintaining the stemness and/or p...
SummaryEpidermal integrity is a complex process established during embryogenesis and maintained thro...
Adult stem cells hold great promise for regenerative medicine, yet it is difficult to expand such ce...
Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, mo...
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution...
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution...
SummaryWnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of W...
The term "Wnt signaling" does not refer to one uniform signal transduction cascade. Instead, it desc...
β-Catenin, a key transducer molecule of Wnt signaling, is required for adult hair follicle growth an...
Although previous reports suggested that canonical Wnt signaling has opposing effects on epidermal a...
CD49f+CD34+ cells, a skin epithelial stem cell (EpSC)-rich population, were prepared from adult mous...
Canonical Wnt signaling support the formation and maintenance of stem and cancer stem cells. Recent ...
The adult human body is built of around 3.72 × 1013 cells. These cells display a great variation in ...
The skin is a classical example of a tissue maintained by stem cells. However, the identity of the s...
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution...
PurposeA chemical approach to examine the role of Wnt signaling in maintaining the stemness and/or p...
SummaryEpidermal integrity is a complex process established during embryogenesis and maintained thro...
Adult stem cells hold great promise for regenerative medicine, yet it is difficult to expand such ce...
Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, mo...
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution...
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution...
SummaryWnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of W...
The term "Wnt signaling" does not refer to one uniform signal transduction cascade. Instead, it desc...
β-Catenin, a key transducer molecule of Wnt signaling, is required for adult hair follicle growth an...
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