SummaryMemory CD8+ T cells are critical for long-term immunity, but the genetic pathways governing their formation remain poorly defined. This study shows that the IL-10-IL-21-STAT3 pathway is critical for memory CD8+ T cell development after acute LCMV infection. In the absence of either interleukin-10 (IL-10) and IL-21 or STAT3, virus-specific CD8+ T cells retain terminal effector (TE) differentiation states and fail to mature into protective memory T cells that contain self-renewing central memory T cells. Expression of Eomes, BCL-6, Blimp-1, and SOCS3 was considerably reduced in STAT3-deficient memory CD8+ T cells, and BCL-6- or SOCS3-deficient CD8+ T cells also had perturbed memory cell development. Reduced SOCS3 expression rendered ST...
Memory CD8 T cells are an integral part of protective immunity against viral infections, however the...
SummaryAs acute infections resolve, effector CD8+ T cells differentiate into interleukin-7 receptorl...
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signa...
SummaryMemory CD8+ T cells are critical for long-term immunity, but the genetic pathways governing t...
The CD8+ T cell response is characterized by generation of a population of effector cells and establ...
International audienceThe developmental origins of memory T cells remain incompletely understood. Du...
Background: The capacity of CD8(+) T cells to control infections and mediate antitumor immunity requ...
SummarySTAT3 transcription factor signaling in specific T helper cell differentiation has been well ...
CD4+ T lymphocytes are a key element of adaptive immunity, acting to coordinate and enhance function...
eeINTRODUCTION After acute viral infections, antigen-specific CD8+ T cells can undergo a memory diff...
SummaryDuring acute infections, a small population of effector CD8+ T cells evades terminal differen...
During an acute infection, activated CD8 T cells undergo a process of differentiation from naïve to ...
Infection with murine cytomegalovirus (MCMV) induces a large population of virus-specific CD8+ T-cel...
Memory CD8 T cells are an important component of pro-tective immunity against viral infections, and ...
Chronic viral infections are widespread among humans, with ∼8–12 chronic viral infections per indivi...
Memory CD8 T cells are an integral part of protective immunity against viral infections, however the...
SummaryAs acute infections resolve, effector CD8+ T cells differentiate into interleukin-7 receptorl...
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signa...
SummaryMemory CD8+ T cells are critical for long-term immunity, but the genetic pathways governing t...
The CD8+ T cell response is characterized by generation of a population of effector cells and establ...
International audienceThe developmental origins of memory T cells remain incompletely understood. Du...
Background: The capacity of CD8(+) T cells to control infections and mediate antitumor immunity requ...
SummarySTAT3 transcription factor signaling in specific T helper cell differentiation has been well ...
CD4+ T lymphocytes are a key element of adaptive immunity, acting to coordinate and enhance function...
eeINTRODUCTION After acute viral infections, antigen-specific CD8+ T cells can undergo a memory diff...
SummaryDuring acute infections, a small population of effector CD8+ T cells evades terminal differen...
During an acute infection, activated CD8 T cells undergo a process of differentiation from naïve to ...
Infection with murine cytomegalovirus (MCMV) induces a large population of virus-specific CD8+ T-cel...
Memory CD8 T cells are an important component of pro-tective immunity against viral infections, and ...
Chronic viral infections are widespread among humans, with ∼8–12 chronic viral infections per indivi...
Memory CD8 T cells are an integral part of protective immunity against viral infections, however the...
SummaryAs acute infections resolve, effector CD8+ T cells differentiate into interleukin-7 receptorl...
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signa...