AbstractWhile studying the developmental functions of the Drosophila dopamine synthesis pathway genes, we noted interesting and unexpected mutant phenotypes in the developing trachea, a tubule network that has been studied as a model for branching morphogenesis. Specifically, Punch (Pu) and pale (ple) mutants with reduced dopamine synthesis show ectopic/aberrant migration, while Catecholamines up (Catsup) mutants that over-express dopamine show a characteristic loss of migration phenotype. We also demonstrate expression of Punch, Ple, Catsup and dopamine in tracheal cells. The dopamine pathway mutant phenotypes can be reproduced by pharmacological treatments of dopamine and a pathway inhibitor 3-iodotyrosine (3-IT), implicating dopamine as ...
BACKGROUND: The pair-rule gene, hairy, encodes a basic helix-loop-helix transcription factor and is ...
AbstractTubes with distinct shapes and sizes are critical for the proper function of many tubular or...
The formation of epithelial tubes with defined shapes and sizes is essential for organ development. ...
AbstractWhile studying the developmental functions of the Drosophila dopamine synthesis pathway gene...
AbstractThe tracheal system of Drosophila embryos achieves its archetypal branching pattern through ...
Summary The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branc...
AbstractProtein kinase B (PKB, also termed Akt) is a phosphatidylinositol 3′ kinase (PI3′K)-dependen...
A stereotyped tubular epithelial network forms many of our bodies’ organs and, defects in the format...
Branched tubular organs, such as the lung and vascular system fulfill the respiratory needs of most ...
AbstractBackground: Branching morphogenesis transforms an epithelial sheet into a tubular network wi...
Tubes are a fundamental unit of organ design. Most of our major organs like the lung, kidney and vas...
AbstractIn the developing tracheal system of Drosophila melanogaster, six major branches arise by gu...
SummaryThe development of air-filled respiratory organs is crucial for survival at birth. We used a ...
Most organs and glands are composed of interconnected networks of tubes. Tubes carryout many importa...
The terminal cells of the larval Drosophila tracheal system extend dozens of branched cellular proce...
BACKGROUND: The pair-rule gene, hairy, encodes a basic helix-loop-helix transcription factor and is ...
AbstractTubes with distinct shapes and sizes are critical for the proper function of many tubular or...
The formation of epithelial tubes with defined shapes and sizes is essential for organ development. ...
AbstractWhile studying the developmental functions of the Drosophila dopamine synthesis pathway gene...
AbstractThe tracheal system of Drosophila embryos achieves its archetypal branching pattern through ...
Summary The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branc...
AbstractProtein kinase B (PKB, also termed Akt) is a phosphatidylinositol 3′ kinase (PI3′K)-dependen...
A stereotyped tubular epithelial network forms many of our bodies’ organs and, defects in the format...
Branched tubular organs, such as the lung and vascular system fulfill the respiratory needs of most ...
AbstractBackground: Branching morphogenesis transforms an epithelial sheet into a tubular network wi...
Tubes are a fundamental unit of organ design. Most of our major organs like the lung, kidney and vas...
AbstractIn the developing tracheal system of Drosophila melanogaster, six major branches arise by gu...
SummaryThe development of air-filled respiratory organs is crucial for survival at birth. We used a ...
Most organs and glands are composed of interconnected networks of tubes. Tubes carryout many importa...
The terminal cells of the larval Drosophila tracheal system extend dozens of branched cellular proce...
BACKGROUND: The pair-rule gene, hairy, encodes a basic helix-loop-helix transcription factor and is ...
AbstractTubes with distinct shapes and sizes are critical for the proper function of many tubular or...
The formation of epithelial tubes with defined shapes and sizes is essential for organ development. ...