Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury
- Haus, Daniel L.
- López-Velázquez, Luci
- Gold, Eric M.
- Cunningham, Kelly M.
- Perez, Harvey
- Anderson, Aileen J.
- Cummings, Brian J.
DOIAbstract
AbstractTraumatic brain injury (TBI) in humans can result in permanent tissue damage and has been linked to cognitive impairment that lasts years beyond the initial insult. Clinically effective treatment strategies have yet to be developed. Transplantation of human neural stem cells (hNSCs) has the potential to restore cognition lost due to injury, however, the vast majority of rodent TBI/hNSC studies to date have evaluated cognition only at early time points, typically <1month post-injury and cell transplantation. Additionally, human cell engraftment and long-term survival in rodent models of TBI has been difficult to achieve due to host immunorejection of the transplanted human cells, which confounds conclusions pertaining to transplant-m...
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