AbstractWnt signaling plays a crucial role in directing cell differentiation, polarity, and growth [1–3]. In the canonical pathway, Wnt receptors activate Dishevelled (Dvl), which then blocks the degradation of a key signal transducer, β-catenin, leading to the nuclear accumulation of β-catenin and induction of Wnt target genes through TCF/LEF family transcription factors [1–3]. Here we identified a novel zebrafish gene encoding Ccd1, which possesses a DIX (Dishevelled-Axin) domain. DIX domains are essential for the signal transduction of two major Wnt downstream mediators, Dvl and Axin. Ccd1 formed homomeric and heteromeric complexes with Dvl and Axin and activated TCF-dependent transcription in vitro. In addition, overexpression of ccd1 i...
Ocular coloboma is a condition caused by a malformation in optic fissure formation during early eye ...
Wnt proteins can activate distinct signaling pathways, but little is known about the mechanisms regu...
SummaryBackground: Wnt/β-catenin signaling regulates many processes during vertebrate development, i...
AbstractWnt signaling plays a crucial role in directing cell differentiation, polarity, and growth [...
Wnt signaling plays an important role in governing cell fate decisions. Coiled-coil-DIX1 (Ccd1), Dis...
AbstractThe establishment of the left–right (LR) axis in zebrafish embryos relies on signals from th...
AbstractAlthough Wnt signaling plays an important role in body patterning during early vertebrate em...
AbstractCaveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively re...
AbstractThe Wnt/β-catenin signaling pathway plays multiple roles during embryonic development, only ...
During early vertebrate embryogenesis, maternal Wnt/beta-catenin signaling is thought to locally ini...
AbstractThe establishment of the vertebrate body plan involves patterning of the ectoderm, mesoderm,...
SummaryDuring regional patterning of the anterior neural plate, a medially positioned domain of cell...
AbstractWnt signaling controls a wide range of developmental processes and its aberrant regulation c...
Wnt signaling plays critical roles in dorsoventral fate specification and anteroposterior patterning...
Zebrafish embryos homozygous for the masterblind(mbl) mutation exhibit a striking phenotype in which...
Ocular coloboma is a condition caused by a malformation in optic fissure formation during early eye ...
Wnt proteins can activate distinct signaling pathways, but little is known about the mechanisms regu...
SummaryBackground: Wnt/β-catenin signaling regulates many processes during vertebrate development, i...
AbstractWnt signaling plays a crucial role in directing cell differentiation, polarity, and growth [...
Wnt signaling plays an important role in governing cell fate decisions. Coiled-coil-DIX1 (Ccd1), Dis...
AbstractThe establishment of the left–right (LR) axis in zebrafish embryos relies on signals from th...
AbstractAlthough Wnt signaling plays an important role in body patterning during early vertebrate em...
AbstractCaveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively re...
AbstractThe Wnt/β-catenin signaling pathway plays multiple roles during embryonic development, only ...
During early vertebrate embryogenesis, maternal Wnt/beta-catenin signaling is thought to locally ini...
AbstractThe establishment of the vertebrate body plan involves patterning of the ectoderm, mesoderm,...
SummaryDuring regional patterning of the anterior neural plate, a medially positioned domain of cell...
AbstractWnt signaling controls a wide range of developmental processes and its aberrant regulation c...
Wnt signaling plays critical roles in dorsoventral fate specification and anteroposterior patterning...
Zebrafish embryos homozygous for the masterblind(mbl) mutation exhibit a striking phenotype in which...
Ocular coloboma is a condition caused by a malformation in optic fissure formation during early eye ...
Wnt proteins can activate distinct signaling pathways, but little is known about the mechanisms regu...
SummaryBackground: Wnt/β-catenin signaling regulates many processes during vertebrate development, i...