Epigenetic changes can contribute to development of acute myeloid leukemia (AML), a malignant disease of the bone marrow. A single-nucleotide polymorphism of transcription factor growth factor independence 1 (GFI1) generates a protein with an asparagine at position 36 (GFI136N) instead of a serine at position 36 (GFI136S), which is associated with de novo AML in humans. However, how GFI136N predisposes to AML is poorly understood. To explore the mechanism, we used knock-in mouse strains expressing GFI136N or GFI136S. Presence of GFI136N shortened the latency and increased the incidence of AML in different murine models of myelodysplastic syndrome/AML. On a molecular level, GFI136N induced genomewide epigenetic changes, leading to expression...
Epigenetic modifications, such as histone modifications and DNA methylation, are essential for ensur...
Epigenetic therapies of cancer have been intensely studied, because of the high frequency of epigene...
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogen...
Epigenetic changes can contribute to development of acute myeloid leukemia (AML), a malignant diseas...
The coding single nucleotide polymorphism GFI136N in the human gene growth factor independence 1 (GF...
The zinc finger protein Growth Factor Independence 1 (GFI1) acts as a transcriptional repressor regu...
The GFI1 gene encodes a transcriptional repressor, which regulates myeloid differentiation. In the m...
Item does not contain fulltextThe GFI1 gene encodes a transcriptional repressor, which regulates mye...
The importance of epigenetic dysregulation to acute myeloid leukemia (AML) pathophysiology has becom...
Acute myeloid leukaemia (AML) is a heterogeneous group of myeloid lineage malignancies arising from ...
Background: Human myelogenous leukemia characterized by either the non random t(8; 21)(q22; q22) or ...
Growth Factor Independence 1 (GFI1) is a transcription factor with an important role in the regulati...
Every day, the hematopoietic system produces billions of blood cells of multiple lineages, with esse...
We identify a mutation (D262N) in the erythroid-affiliated transcriptional repressor GFI1B, in an ac...
Acute myeloid leukemia (AML), the most prevalent acute leukemia in adults, is an aggressive hematolo...
Epigenetic modifications, such as histone modifications and DNA methylation, are essential for ensur...
Epigenetic therapies of cancer have been intensely studied, because of the high frequency of epigene...
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogen...
Epigenetic changes can contribute to development of acute myeloid leukemia (AML), a malignant diseas...
The coding single nucleotide polymorphism GFI136N in the human gene growth factor independence 1 (GF...
The zinc finger protein Growth Factor Independence 1 (GFI1) acts as a transcriptional repressor regu...
The GFI1 gene encodes a transcriptional repressor, which regulates myeloid differentiation. In the m...
Item does not contain fulltextThe GFI1 gene encodes a transcriptional repressor, which regulates mye...
The importance of epigenetic dysregulation to acute myeloid leukemia (AML) pathophysiology has becom...
Acute myeloid leukaemia (AML) is a heterogeneous group of myeloid lineage malignancies arising from ...
Background: Human myelogenous leukemia characterized by either the non random t(8; 21)(q22; q22) or ...
Growth Factor Independence 1 (GFI1) is a transcription factor with an important role in the regulati...
Every day, the hematopoietic system produces billions of blood cells of multiple lineages, with esse...
We identify a mutation (D262N) in the erythroid-affiliated transcriptional repressor GFI1B, in an ac...
Acute myeloid leukemia (AML), the most prevalent acute leukemia in adults, is an aggressive hematolo...
Epigenetic modifications, such as histone modifications and DNA methylation, are essential for ensur...
Epigenetic therapies of cancer have been intensely studied, because of the high frequency of epigene...
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogen...