Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: A pilot study
- Straface, Elisabetta
- Matarrese, Paola
- Gambardella, Lucrezia
- Vona, Rosa
- Sgadari, Antonio
- Silveri, Maria Caterina
- Malorni, Walter
Publication date
May 2005
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.Abstract
AbstractMarkers of oxidative stress in peripheral blood from patients with Alzheimer disease (AD) were analyzed. Thirty-three AD patients were recruited. Plasma antioxidant power (AOP), plasma Cystatin C as well as Cathepsin D in PBL were evaluated. We found that the AOP levels were significantly decreased in AD patients if compared to healthy donors, while the plasma level of Cystatin C was significantly higher. Importantly, a significantly decreased expression of Cathepsin D in PBL was also observed. These results suggest that oxidative imbalance in the peripheral blood of AD patients could mirror oxidative changes previously described in the central nervous system
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