Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. Individuals with DS exhibit changes in neurochemistry and neuroanatomy that worsen with age, neurological delay in learning and memory, and predisposition to Alzheimer’s disease. The Ts65Dn mouse is the best characterized model of DS and has many features reminiscent of DS, including developmental anomalies and age-related neurodegeneration. The mouse carries a partial triplication of mouse chromosome 16 containing roughly 100 genes syntenic to human chromosome 21 genes. We hypothesized that there would be differences in brain metabolites with trisomy and age, and that long-term treatment with rapamycin, mechanistic target of...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...
Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellec...
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzh...
The Ts65Dn is a popular mouse model of Down syndrome (DS). It displays DS-relevant features of learn...
The Ts65Dn is a popular mouse model of Down syndrome (DS). It displays DS-relevant features of learn...
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzh...
Aging is often associated with impaired cognition and a progressive loss of organ function over time...
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzh...
Thesis (Ph.D.)--University of Washington, 2014Treatments to stop or reverse the debilitating progres...
Thesis (Ph.D.)--University of Washington, 2014Treatments to stop or reverse the debilitating progres...
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in ...
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in ...
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in ...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...
Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellec...
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzh...
The Ts65Dn is a popular mouse model of Down syndrome (DS). It displays DS-relevant features of learn...
The Ts65Dn is a popular mouse model of Down syndrome (DS). It displays DS-relevant features of learn...
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzh...
Aging is often associated with impaired cognition and a progressive loss of organ function over time...
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzh...
Thesis (Ph.D.)--University of Washington, 2014Treatments to stop or reverse the debilitating progres...
Thesis (Ph.D.)--University of Washington, 2014Treatments to stop or reverse the debilitating progres...
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in ...
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in ...
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in ...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...
Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age ...