OXIDIZED LOW-DENSITY PROTEIN, INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR ALPHA LEVELS AND PARAOXONASE ACTIVITIES IN HYPERTENSIVE PATIENTS

Oxidative stress is thought to play a critical role in the pathogenesis of essential hypertension. Oxidized low-density lipoprotein (ox-LDL) has an important role during the atherosclerosis process and paraoxonase can significantly inhibit lipid peroxidation. We aimed to examine serum oxidized LDL, TNFa, LL-6 levels and paraoxonase (P0N1) activity as a biomarkers of oxidative stress in hypertensive patients. Thirty-eight hypertensive patients and twenty-two healthy control subjects were included in the study. Clinical assessment and blood pressure measurement were performed in patients. Serum Ox-LDL, TNF-a and LL-6 levels were measured by Enzyme-linked immunosorbent assay (ELLSA) method. P0N1 activities were measured by spectrophotometric method. Ox-LDL and LL-6 levels were significantly higher in hypertensive patients compared to controls ((p<0.01, p<0.01, respectively). P0N1 activities were found higher in dipper patients than those of non-dipper patients ((p