Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces species. The cellular target of LMB has been identified as the nuclear export receptor CRM-1 or exportin-1, which is involved in nuclear trafficking of cellular RNAs or proteins containing the nuclear export sequence (NES). CRM-1 is the main mediator of nuclear export in many cell types including hepatocyte cell lines. The ability of LMB to inhibit nuclear export has made it a useful tool in the study of the intracellular localization of many regulatory proteins. In this study, we evaluated the effect of nuclear export inhibitor LMB treatment on the intracellular localization of HBV core protein into the hepatocyte cell lines, Huh-7 and HepG2 c...
<p>(A) Effect of leptomycin B on localization of MIER1α and MIER1-3Aα. Cells were transfected, treat...
<div><p>The hepatitis C virus (HCV) is a positive strand RNA virus of the <i>Flavivirus</i> family t...
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establis...
Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp...
Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp...
<p>(a) Immunofluorescence of cyclin B1 used as a positive control for nuclear export inhibition in c...
<p><b>A)</b> RanBPM shRNA Hela cells transfected with 840 WT NLS1/NES were treated with ethanol (EtO...
<p>(A) Production of the EGFP-labeled core protein aa(1–173) in Huh7 cells results in the presence o...
AbstractBackground: The human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev is requir...
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. HCV core prot...
(A) Schematic representation of protein nuclear export via nuclear pore complexes mediated by the in...
Leptomycin B (LMB) is a Streptomyces metabolite that causes the specific inhibition of the nuclear e...
<p><b>A</b>, localisation patterns for PAPS synthase wild-type fusion proteins following LMB treatme...
It remains unclear what determines the subcellular localization of hepatitis B virus (HBV) core prot...
Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recogniz...
<p>(A) Effect of leptomycin B on localization of MIER1α and MIER1-3Aα. Cells were transfected, treat...
<div><p>The hepatitis C virus (HCV) is a positive strand RNA virus of the <i>Flavivirus</i> family t...
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establis...
Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp...
Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp...
<p>(a) Immunofluorescence of cyclin B1 used as a positive control for nuclear export inhibition in c...
<p><b>A)</b> RanBPM shRNA Hela cells transfected with 840 WT NLS1/NES were treated with ethanol (EtO...
<p>(A) Production of the EGFP-labeled core protein aa(1–173) in Huh7 cells results in the presence o...
AbstractBackground: The human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev is requir...
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. HCV core prot...
(A) Schematic representation of protein nuclear export via nuclear pore complexes mediated by the in...
Leptomycin B (LMB) is a Streptomyces metabolite that causes the specific inhibition of the nuclear e...
<p><b>A</b>, localisation patterns for PAPS synthase wild-type fusion proteins following LMB treatme...
It remains unclear what determines the subcellular localization of hepatitis B virus (HBV) core prot...
Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recogniz...
<p>(A) Effect of leptomycin B on localization of MIER1α and MIER1-3Aα. Cells were transfected, treat...
<div><p>The hepatitis C virus (HCV) is a positive strand RNA virus of the <i>Flavivirus</i> family t...
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establis...