Previous data obtained in our laboratory suggested that there may be constitutive signaling through the myeloid differentiation primary response gene 88 (Myd88)-dependent signaling cascade in murine mammary carcinoma. Here, we extended these findings by showing that, in the absence of an added Toll-like receptor (TLR) agonist, the myddosome complex was preformed in 4T1 tumor cells, and that Myd88 influenced cytoplasmic extracellular signal–regulated kinase (Erk)1/Erk2 levels, nuclear levels of nuclear factor-kappaB (NFκB) and signal transducer and activator of transcription 5 (STAT5), tumor-derived chemokine (C–C motif) ligand 2 (CCL2) expression, and in vitro and in vivo tumor growth. In addition, RNA-sequencing revealed that Myd88-depende...
Breast cancer is one of the most common malignancies in women. It continues to be a major burden and...
Background/aimInflammation may play a role in cancer initiation and progression. The molecular mecha...
MyD88 est une protéine adaptatrice du système immunitaire inné, impliquée dans la défense de l’organ...
The mechanisms that link inflammatory responses to cancer development remain a subject of intense in...
The role of immune signaling in cancer is complex and conflicting. Inflammatory signaling can drive ...
Here we report the effects of loss of the Toll-like receptor-associated signaling adaptor myeloid-di...
<div><p>MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically activ...
THESIS 11177Tumour-initiating cells are known to share some properties with stem cells. These so cal...
MyD88, an adaptor molecule downstream of innate pathways, plays a significant tumor-promoting role i...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
MyD88, an adaptor molecule downstream of innate pathways, plays a significant tumor-promoting role i...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
We have previously reported that myeloid differentiation primary response gene 88 (MyD88) is downreg...
MYB oncogene upregulation is associated with estrogen receptor (ER)-positive breast cancer, but dise...
Breast cancer is one of the most common malignancies in women. It continues to be a major burden and...
Background/aimInflammation may play a role in cancer initiation and progression. The molecular mecha...
MyD88 est une protéine adaptatrice du système immunitaire inné, impliquée dans la défense de l’organ...
The mechanisms that link inflammatory responses to cancer development remain a subject of intense in...
The role of immune signaling in cancer is complex and conflicting. Inflammatory signaling can drive ...
Here we report the effects of loss of the Toll-like receptor-associated signaling adaptor myeloid-di...
<div><p>MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically activ...
THESIS 11177Tumour-initiating cells are known to share some properties with stem cells. These so cal...
MyD88, an adaptor molecule downstream of innate pathways, plays a significant tumor-promoting role i...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
MyD88, an adaptor molecule downstream of innate pathways, plays a significant tumor-promoting role i...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresista...
We have previously reported that myeloid differentiation primary response gene 88 (MyD88) is downreg...
MYB oncogene upregulation is associated with estrogen receptor (ER)-positive breast cancer, but dise...
Breast cancer is one of the most common malignancies in women. It continues to be a major burden and...
Background/aimInflammation may play a role in cancer initiation and progression. The molecular mecha...
MyD88 est une protéine adaptatrice du système immunitaire inné, impliquée dans la défense de l’organ...