Adipose tissue is an attractive stem cell source for soft and bone tissue engineering applications and stem cell therapies. The adipose-derived stromal/stem cells (ASCs) have a multilineage differentiation capacity that is regulated through extracellular signals. The cellular events related to cell adhesion and cytoskeleton have been suggested as central regulators of differentiation fate decision. However, the detailed knowledge of these molecular mechanisms in human ASCs remains limited. This study examined the significance of focal adhesion kinase (FAK), Rho-Rho-associated protein kinase (Rho-ROCK), and their downstream target extracellular signal-regulated kinase 1/2 (ERK1/2) on hASCs differentiation towards osteoblasts and adipocytes. ...
Human stromal stem cells (hMSCs) differentiate into adipocytes that play a role in skeletal tissue h...
It has previously been demonstrated that cell shape can influence commitment of human bone marrow-de...
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as oste...
Adipose tissue is an attractive stem cell source for soft and bone tissue engineering applications a...
There is considerable attention regarding the role of receptor signaling and downstream-regulated me...
There is considerable attention regarding the role of receptor signaling and downstream-regulated me...
<p><b><i>Overview</i></b>: The use of pro-osteogenic growth factors, such as BMP2, in human adipose-...
Background aims. Human (h) adipose tissue-derived mesenchymal stromal cells (ASC) constitute an inte...
AMP-activated protein kinase (AMPK) is an energy-sensing kinase that has recently been shown to regu...
Decreased bone formation is often associated with increased bone marrow adiposity. The molecular mec...
ABSTRACT: The compliance of the extracellular matrix (ECM) regulates osteogenic differentiation by m...
The four R-spondins ( RSPOs) and their three related receptors, LGR4, 5 and 6, have emerged as a maj...
Abstract Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is classically thought...
Human umbilical cord mesenchymal stem cells (hUCMSCs) are recognized as candidate progenitor cells f...
Abstract: There is considerable attention regarding the role of receptor signaling and downstream-re...
Human stromal stem cells (hMSCs) differentiate into adipocytes that play a role in skeletal tissue h...
It has previously been demonstrated that cell shape can influence commitment of human bone marrow-de...
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as oste...
Adipose tissue is an attractive stem cell source for soft and bone tissue engineering applications a...
There is considerable attention regarding the role of receptor signaling and downstream-regulated me...
There is considerable attention regarding the role of receptor signaling and downstream-regulated me...
<p><b><i>Overview</i></b>: The use of pro-osteogenic growth factors, such as BMP2, in human adipose-...
Background aims. Human (h) adipose tissue-derived mesenchymal stromal cells (ASC) constitute an inte...
AMP-activated protein kinase (AMPK) is an energy-sensing kinase that has recently been shown to regu...
Decreased bone formation is often associated with increased bone marrow adiposity. The molecular mec...
ABSTRACT: The compliance of the extracellular matrix (ECM) regulates osteogenic differentiation by m...
The four R-spondins ( RSPOs) and their three related receptors, LGR4, 5 and 6, have emerged as a maj...
Abstract Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is classically thought...
Human umbilical cord mesenchymal stem cells (hUCMSCs) are recognized as candidate progenitor cells f...
Abstract: There is considerable attention regarding the role of receptor signaling and downstream-re...
Human stromal stem cells (hMSCs) differentiate into adipocytes that play a role in skeletal tissue h...
It has previously been demonstrated that cell shape can influence commitment of human bone marrow-de...
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as oste...