High-grade serous ovarian cancer is a deadly disease that can originate from the fallopian tube or the ovarian surface epithelium. The PAX (paired box) genes PAX2 and PAX8 are lineage-specific transcription factors required during development of the fallopian tube but not in the development of the ovary. PAX2 expression is lost early in serous cancer progression, while PAX8 is expressed ubiquitously. These proteins are implicated in migration, invasion, proliferation, cell survival, stem cell maintenance, and tumor growth. Hence, targeting PAX2 and PAX8 represents a promising drug strategy that could inhibit these pro-tumorigenic effects. In this review, we examine the implications of PAX2 and PAX8 expression in the cell of origin of serous...
Background: Ovarian cancer is the third most common cause of death among gynecologic malignancies wo...
PAX2 is one of nine PAX genes regulating tissue development and cellular differentiation in embryos....
Introduction and aim. Paired box 8 (PAX-8) is a specific transcription factor known as a protein pro...
High-grade serous ovarian cancer is a deadly disease that can originate from the fallopian tube or t...
PAX2 is one of nine PAX genes that regulate tissue development and cellular differentiation in embry...
PAX2 is one of nine PAX genes that regulate tissue development and cellular differentiation in embry...
Understanding the biology and molecular pathogenesis of ovarian epithelial cancer (EOC) is key to de...
Understanding the biology and molecular pathogenesis of ovarian epithelial cancer (EOC) is key to de...
Understanding the biology and molecular pathogenesis of ovarian epithelial cancer (EOC) is key to de...
PAX2 is one of nine PAX genes regulating tissue development and cellular differentiation in embryos....
Objectives. Epithelial ovarian carcinomas develop from ovarian surface epithelia that undergo co...
Ovarian cancer is the most deadly gynecological malignancy in the US. Once thought to be a single di...
PAX8 is a member of the Paired box (PAX) multigene family of transcription factors, which are involv...
Several studies have proposed the fallopian tube epithelium as a site of origin of ovarian cancer. T...
Background: Ovarian cancer is the third most common cause of death among gynecologic malignancies wo...
Background: Ovarian cancer is the third most common cause of death among gynecologic malignancies wo...
PAX2 is one of nine PAX genes regulating tissue development and cellular differentiation in embryos....
Introduction and aim. Paired box 8 (PAX-8) is a specific transcription factor known as a protein pro...
High-grade serous ovarian cancer is a deadly disease that can originate from the fallopian tube or t...
PAX2 is one of nine PAX genes that regulate tissue development and cellular differentiation in embry...
PAX2 is one of nine PAX genes that regulate tissue development and cellular differentiation in embry...
Understanding the biology and molecular pathogenesis of ovarian epithelial cancer (EOC) is key to de...
Understanding the biology and molecular pathogenesis of ovarian epithelial cancer (EOC) is key to de...
Understanding the biology and molecular pathogenesis of ovarian epithelial cancer (EOC) is key to de...
PAX2 is one of nine PAX genes regulating tissue development and cellular differentiation in embryos....
Objectives. Epithelial ovarian carcinomas develop from ovarian surface epithelia that undergo co...
Ovarian cancer is the most deadly gynecological malignancy in the US. Once thought to be a single di...
PAX8 is a member of the Paired box (PAX) multigene family of transcription factors, which are involv...
Several studies have proposed the fallopian tube epithelium as a site of origin of ovarian cancer. T...
Background: Ovarian cancer is the third most common cause of death among gynecologic malignancies wo...
Background: Ovarian cancer is the third most common cause of death among gynecologic malignancies wo...
PAX2 is one of nine PAX genes regulating tissue development and cellular differentiation in embryos....
Introduction and aim. Paired box 8 (PAX-8) is a specific transcription factor known as a protein pro...