Effect of Primidone on Pituitary-Thyroid Axis and Thyroid Tissue Changes in Newborn Male Rats from Mothers

Background: Thyroid is an important organ with special function in metabolism of drugs. Primidone is a drugs for treatment of some patients including epilepsy. The present study was conducted to evaluate the effect Primidone on thyroid hormones function including T3,T4 and TSH and histological changes of thyroid newborn male rats. Material and Methods: In this experimental study, 40 newborn male rats wistar strain divided into 5 group of 8 .The newborns were taken from pregnant mothers divided to the control group, the sham group and three experimental groups that received 20, 40 and 60 mg/kg b.w. primidone in the pregnancy period for 21 days orally. In 25 days after parturition, the newborns weighted and T3,T4 and TSH hormone assay. The newborns thyroid tissue evaluated by H&E histological staining methods. Results: Body weight and thyroid weight in different experimental groups show did not significant difference compared to the control group. Concentration of TSH and T3 hormones in different experimental groups show did not significant difference compared to the control group. Also, serum level of T4 hormone in experimental groups 2,3 show a significant decrease compared to the control group. In tissue tissue samples with increasing doses of the drug was observed more necrosis. Conclusion: Primidone has destructive effects on Thyroid gland