Ranibizumab for choroidal neovascularization following atrophic involution of adult-onset foveomacular vitelliform dystrophy.

Purpose: We report a case of adult-onset foveomacular vitelliform dystrophy (AOFVD) complicated with atrophic involution and subsequent choroidal neovascularization (CNV) and treated with intravitreal ranibizumab. Design: Case Report Methods: A 71-year-old woman diagnosed with AOFVD experienced a progression of the vitelliform lesion to the atrophic stage in her left eye immediately after cataract surgery. Best corrected visual acuity (BCVA) decreased from 0.5 to 0.16. Ten months later, the patient was referred with new worsening of her visual acuity (0.05) and metamorphopsia. The spectral-domain optical coherence tomography (SD-OCT) confirmed the presence of type 2 CNV next to the atrophic area. The patient was treated with 2 monthly injections of ranibizumab. Results: SD-OCT images improved significantly and her BCVA increased to 0.20 associated with subjective improvement of metamorphopsia. Conclusion: Ranibizumab may be effective for CNV in patients with AOFVD